SLC7A11 as a biomarker and therapeutic target in HPV-positive head and neck Squamous Cell Carcinoma.
Acetylcysteine
/ metabolism
Amino Acid Transport System y+
/ antagonists & inhibitors
Biological Transport, Active
/ drug effects
Biomarkers
/ metabolism
Cell Line, Tumor
Cystine
/ metabolism
Ferroptosis
/ drug effects
Gene Expression Regulation, Neoplastic
/ drug effects
Glutathione
/ metabolism
Head and Neck Neoplasms
/ genetics
Human papillomavirus 16
/ metabolism
Humans
Oncogene Proteins, Viral
/ metabolism
Papillomavirus E7 Proteins
/ metabolism
Papillomavirus Infections
/ virology
Phospholipid Hydroperoxide Glutathione Peroxidase
/ antagonists & inhibitors
Piperazines
/ pharmacology
RNA-Seq
Repressor Proteins
/ metabolism
Single-Cell Analysis
Squamous Cell Carcinoma of Head and Neck
/ genetics
Erastin
Ferroptosis
HNSCC
Human papillomavirus 16
SLC7A11
Journal
Biochemical and biophysical research communications
ISSN: 1090-2104
Titre abrégé: Biochem Biophys Res Commun
Pays: United States
ID NLM: 0372516
Informations de publication
Date de publication:
17 12 2020
17 12 2020
Historique:
received:
10
09
2020
accepted:
29
09
2020
pubmed:
7
10
2020
medline:
27
3
2021
entrez:
6
10
2020
Statut:
ppublish
Résumé
Ferroptosis, a regulated form of cell necrosis was previously reported to be induced upon pharmacological targeting of the cystine transporter SLC7A11 in Head and neck Squamous Cell Carcinoma (HNSCC). Whether tumors arising in a context of chronic infection with Human Papillomavirus (HPV) are sensitive to ferroptosis is unknown. Using RNAseq data (both whole-tumor and single-cell sequencing) we report that HPV positive (HPV
Identifiants
pubmed: 33019976
pii: S0006-291X(20)31896-9
doi: 10.1016/j.bbrc.2020.09.134
pii:
doi:
Substances chimiques
Amino Acid Transport System y+
0
Biomarkers
0
E6 protein, Human papillomavirus type 16
0
Oncogene Proteins, Viral
0
Papillomavirus E7 Proteins
0
Piperazines
0
Repressor Proteins
0
SLC7A11 protein, human
0
erastin
0
Cystine
48TCX9A1VT
Phospholipid Hydroperoxide Glutathione Peroxidase
EC 1.11.1.12
Glutathione
GAN16C9B8O
Acetylcysteine
WYQ7N0BPYC
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1083-1087Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.