Regulation of meiotic progression by Sertoli-cell androgen signaling.
Androgens
/ metabolism
Animals
Male
Meiosis
/ physiology
Meiotic Prophase I
Mice
Mice, Inbred C57BL
Mice, Knockout
Prophase
Receptors, Androgen
/ metabolism
Sequence Analysis, RNA
/ methods
Sertoli Cells
/ metabolism
Signal Transduction
Single-Cell Analysis
/ methods
Spermatocytes
/ metabolism
Spermatogenesis
/ physiology
Testis
/ metabolism
Journal
Molecular biology of the cell
ISSN: 1939-4586
Titre abrégé: Mol Biol Cell
Pays: United States
ID NLM: 9201390
Informations de publication
Date de publication:
01 12 2020
01 12 2020
Historique:
pubmed:
8
10
2020
medline:
14
7
2021
entrez:
7
10
2020
Statut:
ppublish
Résumé
Androgen receptor (AR) signaling in Sertoli cells is known to be important for germ-cell progression through meiosis, but the extent to which androgens indirectly regulate specific meiotic stages is not known. Here, we combine synchronization of spermatogenesis, cytological analyses and single-cell RNAseq (scRNAseq) in the
Identifiants
pubmed: 33026960
doi: 10.1091/mbc.E20-05-0334
pmc: PMC7851862
doi:
Substances chimiques
Androgens
0
Receptors, Androgen
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2841-2862Subventions
Organisme : NICHD NIH HHS
ID : F30 HD097961
Pays : United States
Organisme : NICHD NIH HHS
ID : DP2 HD091949
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA034196
Pays : United States
Organisme : NICHD NIH HHS
ID : T32 HD079342
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007863
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD033816
Pays : United States
Organisme : NICHD NIH HHS
ID : R21 HD090371
Pays : United States
Références
Proc Natl Acad Sci U S A. 2004 Feb 3;101(5):1327-32
pubmed: 14745012
Cell. 2015 May 21;161(5):1202-1214
pubmed: 26000488
Biol Reprod. 2018 Jul 1;99(1):112-126
pubmed: 29385397
Proc Natl Acad Sci U S A. 2004 May 4;101(18):6876-81
pubmed: 15107499
Dev Biol. 2013 Aug 15;380(2):145-56
pubmed: 23727514
Dev Biol. 1995 Jun;169(2):557-67
pubmed: 7781899
Mol Endocrinol. 2014 Jul;28(7):1055-72
pubmed: 24825397
J Cell Sci. 2012 Nov 1;125(Pt 21):5061-72
pubmed: 22854038
Mol Endocrinol. 2014 Apr;28(4):575-91
pubmed: 24606126
Elife. 2019 Jun 25;8:
pubmed: 31237565
Oncotarget. 2016 Apr 5;7(14):18722-35
pubmed: 26959739
Biol Reprod. 2015 Feb;92(2):37
pubmed: 25519186
Biol Reprod. 2013 Feb 14;88(2):40
pubmed: 23284139
Am J Hum Genet. 2013 Sep 5;93(3):561-70
pubmed: 23993197
Cytogenet Genome Res. 2003;103(3-4):277-84
pubmed: 15051948
Physiol Rev. 2016 Jan;96(1):1-17
pubmed: 26537427
PLoS Genet. 2015 Dec 08;11(12):e1005690
pubmed: 26646932
Chromosome Res. 1997 Aug;5(5):313-24
pubmed: 9292236
Biol Reprod. 1996 Nov;55(5):975-83
pubmed: 8902206
J Cell Sci. 2002 Sep 1;115(Pt 17):3491-6
pubmed: 12154079
Biol Reprod. 2010 Nov;83(5):759-66
pubmed: 20650881
Nat Biotechnol. 2018 Jun;36(5):411-420
pubmed: 29608179
J Clin Invest. 2000 Dec;106(12):1531-9
pubmed: 11120760
Cell Res. 2018 Sep;28(9):879-896
pubmed: 30061742
Cell. 2016 Aug 25;166(5):1308-1323.e30
pubmed: 27565351
Dev Biol. 1999 Jan 1;205(1):49-64
pubmed: 9882497
Mol Cell Biol. 2000 Mar;20(6):2122-8
pubmed: 10688658
Best Pract Res Clin Endocrinol Metab. 2015 Aug;29(4):595-605
pubmed: 26303086
Bioinformatics. 2013 Jan 1;29(1):15-21
pubmed: 23104886
Mol Biol Cell. 2019 Mar 1;30(5):717-728
pubmed: 30649999
BMC Genomics. 2016 Aug 12;17(1):628
pubmed: 27519264
Genesis. 2002 Jul;33(3):114-8
pubmed: 12124943
BMC Genomics. 2012 Oct 04;13:526
pubmed: 23033966
Endocrinology. 2001 Jun;142(6):2405-8
pubmed: 11356688
Nat Commun. 2019 Feb 15;10(1):777
pubmed: 30770815
Biol Reprod. 2005 May;72(5):1151-60
pubmed: 15659706
Cytogenetics. 1964;3:289-94
pubmed: 14248459
Dev Cell. 2018 Sep 10;46(5):651-667.e10
pubmed: 30146481
PLoS Genet. 2011 Sep;7(9):e1002248
pubmed: 21912526
Neural Comput. 2004 Dec;16(12):2639-64
pubmed: 15516276
Chromosoma. 2008 Oct;117(5):471-85
pubmed: 18563426
Int J Androl. 2010 Jun 1;33(3):507-17
pubmed: 19392831