Gene repression in S. cerevisiae-looking beyond Sir-dependent gene silencing.
Epigenetic transmission
Gene repression
Histone deacetylases
Histone methyl transferases
Non-coding RNA
S. cerevisiae
Journal
Current genetics
ISSN: 1432-0983
Titre abrégé: Curr Genet
Pays: United States
ID NLM: 8004904
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
29
06
2020
accepted:
24
09
2020
revised:
08
09
2020
pubmed:
11
10
2020
medline:
7
7
2021
entrez:
10
10
2020
Statut:
ppublish
Résumé
Gene silencing by the SIR (Silent Information Region) family of proteins in S. cerevisiae has been extensively studied and has served as a founding paradigm for our general understanding of gene repression and its links to histone deacetylation and chromatin structure. In recent years, our understanding of other mechanisms of gene repression in S.cerevisiae was significantly advanced. In this review, we focus on such Sir-independent mechanisms of gene repression executed by various Histone Deacetylases (HDACs) and Histone Methyl Transferases (HMTs). We focus on the genes regulated by these enzymes and their known mechanisms of action. We describe the cooperation and redundancy between HDACs and HMTs, and their involvement in gene repression by non-coding RNAs or by their non-histone substrates. We also propose models of epigenetic transmission of the chromatin structures produced by these enzymes and discuss these in the context of gene repression phenomena in other organisms. These include the recycling of the epigenetic marks imposed by HMTs or the recycling of the complexes harboring HDACs.
Identifiants
pubmed: 33037902
doi: 10.1007/s00294-020-01114-7
pii: 10.1007/s00294-020-01114-7
doi:
Substances chimiques
Chromatin
0
Histones
0
Silent Information Regulator Proteins, Saccharomyces cerevisiae
0
Histone Methyltransferases
EC 2.1.1.-
Histone Deacetylases
EC 3.5.1.98
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
3-17Subventions
Organisme : Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada
ID : RGPIN-2015-06727
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