One-step eantioselective bioresolution for (S)-2-chlorophenylglycine methyl ester catalyzed by the immobilized Protease 6SD on multi-walled carbon nanotubes in a triphasic system.
(S)-2-chlorophenylglycine methyl ester
Enantioselective bioresolution
Immobilization
Protease
Triphasic system
Journal
Journal of biotechnology
ISSN: 1873-4863
Titre abrégé: J Biotechnol
Pays: Netherlands
ID NLM: 8411927
Informations de publication
Date de publication:
10 Jan 2021
10 Jan 2021
Historique:
received:
18
04
2020
revised:
27
09
2020
accepted:
06
10
2020
pubmed:
12
10
2020
medline:
25
9
2021
entrez:
11
10
2020
Statut:
ppublish
Résumé
(S)-2-chlorophenylglycine methyl ester ((S)-1) is a key chiral building block of clopidogrel, which is a widely administered antiaggregatory and antithrombotic drug. Herein, Protease 6SD was covalently immobilized on multi-walled carbon nanotubes (MWCNT), and the as-prepared immobilizate P-6SD@NH
Identifiants
pubmed: 33039550
pii: S0168-1656(20)30271-6
doi: 10.1016/j.jbiotec.2020.10.007
pii:
doi:
Substances chimiques
Enzymes, Immobilized
0
Esters
0
Nanotubes, Carbon
0
Peptide Hydrolases
EC 3.4.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
294-302Informations de copyright
Copyright © 2020. Published by Elsevier B.V.