A functional context for heterogeneity of the circadian clock in cells.
Journal
PLoS biology
ISSN: 1545-7885
Titre abrégé: PLoS Biol
Pays: United States
ID NLM: 101183755
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
revised:
17
11
2020
pubmed:
15
10
2020
medline:
15
12
2020
entrez:
14
10
2020
Statut:
epublish
Résumé
Characterization of circadian systems at the organism level-a top-down approach-has led to definition of unifying properties, a hallmark of the science of chronobiology. The next challenge is to use a bottom-up approach to show how the molecular workings of the cellular circadian clock work as building blocks of those properties. We review new studies, including a recently published PLOS Biology paper by Nikhil and colleagues, that show how programmed but also stochastic generation of variation in cellular circadian period explain important adaptive features of entrained circadian phase.
Identifiants
pubmed: 33052900
doi: 10.1371/journal.pbio.3000927
pii: PBIOLOGY-D-20-02218
pmc: PMC7671520
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment
Langues
eng
Sous-ensembles de citation
IM
Pagination
e3000927Subventions
Organisme : NIGMS NIH HHS
ID : R15 GM126545
Pays : United States
Commentaires et corrections
Type : CommentOn
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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