Multimorbidity in asthma, association with allergy, inflammatory markers and symptom burden, results from the Swedish GA
Adult
Anxiety
/ psychology
Asthma
/ metabolism
Biomarkers
Cell Adhesion Molecules
/ metabolism
Cost of Illness
Depression
/ psychology
Dermatitis, Atopic
/ metabolism
Female
Forced Expiratory Volume
Fractional Exhaled Nitric Oxide Testing
Humans
Hypersensitivity
/ metabolism
Immunoglobulin E
/ metabolism
Inflammation
/ metabolism
Male
Middle Aged
Multimorbidity
Quality of Life
Rhinitis, Allergic
/ metabolism
Skin Tests
Sleep Initiation and Maintenance Disorders
/ physiopathology
Sweden
IgE
asthma
atopic dermatitis
food allergy
rhinitis
Journal
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
ISSN: 1365-2222
Titre abrégé: Clin Exp Allergy
Pays: England
ID NLM: 8906443
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
27
05
2020
revised:
10
09
2020
accepted:
03
10
2020
pubmed:
15
10
2020
medline:
15
1
2022
entrez:
14
10
2020
Statut:
ppublish
Résumé
Asthma is common worldwide and a large part of subjects with asthma have concomitant allergic multimorbidity in the form of rhinitis and/or eczema. The aim of this study is to investigate whether the presence of allergic multimorbidity in asthma relates to allergic sensitization, allergic and respiratory symptoms, quality of life, inflammatory markers, lung function, use of medication and background factors. A total of 437 asthmatics from the (GA Subjects with asthma, rhinitis and eczema were more likely to be sensitized to seasonal allergens (67% vs 32%, P < .001), food allergens (54% vs 18%, P < .001) and to have a higher degree of sensitization than subjects with only asthma (23% vs 10%, P < .001). Subjects with allergic multimorbidity more often had allergic reactions to food (28% vs 10%, P = .002), more respiratory symptoms and anxiety/depression (40% vs, 14%, P < .001) than subjects with only asthma, despite having similar levels of type 2 inflammatory markers. Individuals with allergic multimorbidity were more likely to be diagnosed with asthma before the age of 12 (48% vs 27%, P = .016) and to have maternal heredity for allergy (53% vs 33%, P = .011) than subjects with only asthma. Asthmatics with allergic multimorbidity are more likely to be sensitized to seasonal aeroallergens, food allergens and they have a higher degree of sensitization compared with those with only asthma. Allergic multimorbidity is associated with respiratory and allergy symptoms, anxiety and/or depression.
Sections du résumé
BACKGROUND
Asthma is common worldwide and a large part of subjects with asthma have concomitant allergic multimorbidity in the form of rhinitis and/or eczema.
OBJECTIVE
The aim of this study is to investigate whether the presence of allergic multimorbidity in asthma relates to allergic sensitization, allergic and respiratory symptoms, quality of life, inflammatory markers, lung function, use of medication and background factors.
METHODS
A total of 437 asthmatics from the (GA
RESULTS
Subjects with asthma, rhinitis and eczema were more likely to be sensitized to seasonal allergens (67% vs 32%, P < .001), food allergens (54% vs 18%, P < .001) and to have a higher degree of sensitization than subjects with only asthma (23% vs 10%, P < .001). Subjects with allergic multimorbidity more often had allergic reactions to food (28% vs 10%, P = .002), more respiratory symptoms and anxiety/depression (40% vs, 14%, P < .001) than subjects with only asthma, despite having similar levels of type 2 inflammatory markers. Individuals with allergic multimorbidity were more likely to be diagnosed with asthma before the age of 12 (48% vs 27%, P = .016) and to have maternal heredity for allergy (53% vs 33%, P = .011) than subjects with only asthma.
CONCLUSION AND CLINICAL RELEVANCE
Asthmatics with allergic multimorbidity are more likely to be sensitized to seasonal aeroallergens, food allergens and they have a higher degree of sensitization compared with those with only asthma. Allergic multimorbidity is associated with respiratory and allergy symptoms, anxiety and/or depression.
Identifiants
pubmed: 33053244
doi: 10.1111/cea.13759
pmc: PMC7983924
doi:
Substances chimiques
Biomarkers
0
Cell Adhesion Molecules
0
POSTN protein, human
0
Immunoglobulin E
37341-29-0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
262-272Informations de copyright
© 2020 The Authors. Clinical & Experimental Allergy published by John Wiley & Sons Ltd.
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