Macrophages promote endothelial-to-mesenchymal transition via MT1-MMP/TGFβ1 after myocardial infarction.

Animals Collagen / metabolism Disease Models, Animal Endothelium, Vascular / metabolism Epithelial-Mesenchymal Transition Female Fibrosis Flow Cytometry Gene Expression Regulation HEK293 Cells Humans Macrophages / metabolism Male Matrix Metalloproteinase 14 / metabolism Mice Mice, Inbred C57BL Mice, Knockout Microcirculation Myocardial Infarction / metabolism Phenotype Reperfusion Injury Transforming Growth Factor beta1 / metabolism Ventricular Dysfunction, Left
MT1-MMP TGFB1 endothelial cells immunology inflammation macrophages mouse myocardial infarction regenerative medicine stem cells tissue remodeling

Journal

eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614

Informations de publication

Date de publication:
16 10 2020
Historique:
received: 15 04 2020
accepted: 15 10 2020
pubmed: 17 10 2020
medline: 15 5 2021
entrez: 16 10 2020
Statut: epublish

Résumé

Macrophages (Mφs) produce factors that participate in cardiac repair and remodeling after myocardial infarction (MI); however, how these factors crosstalk with other cell types mediating repair is not fully understood. Here we demonstrated that cardiac Mφs increased the expression of

Identifiants

DOI: 10.7554/eLife.57920 PMID: 33063665 PMC: PMC7609061
pubmed: 33063665
doi: 10.7554/eLife.57920
pii: 57920
pmc: PMC7609061
doi:
pii:

Substances chimiques

Mmp14 protein, mouse 0
Tgfb1 protein, mouse 0
Transforming Growth Factor beta1 0
Collagen 9007-34-5
Matrix Metalloproteinase 14 EC 3.4.24.80

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Spanish Ministry of Science, Innovation and Universities
ID : SAF2017-90604-REDT-NurCaMein
Pays : International
Organisme : Spanish Ministry of Science, Innovation and Universities
ID : RTI2018-095928-BI00
Pays : International
Organisme : Spanish Ministry of Science, Innovation and Universities
ID : SAF2017-83229-R
Pays : International
Organisme : Comunidad de Madrid
ID : MOIR-B2017/BMD-3684
Pays : International
Organisme : Spanish Ministry of Science, Innovation and Universities
ID : SAF2017-90604-REDT-NurCaMeIn
Pays : International
Organisme : Spanish Ministry of Science and Innovation
ID : BES-2016-076632
Pays : International

Commentaires et corrections

Type : CommentIn

Informations de copyright

© 2020, Alonso-Herranz et al.

Déclaration de conflit d'intérêts

LA, ÁS, AP, PG, PG, VN, CC, MC, MV, JI, DG, AA, MR No competing interests declared

Références

Mol Cell Biochem. 2001 Mar;219(1-2):163-70
pubmed: 11354248
Int J Cardiol. 2013 Sep 30;168(2):1711-4
pubmed: 23608402
J Exp Med. 2007 Nov 26;204(12):3037-47
pubmed: 18025128
Circulation. 2010 Oct 5;122(14):1396-404
pubmed: 20855659
J Struct Biol. 2010 Jan;169(1):36-44
pubmed: 19651220
Dis Model Mech. 2011 Jul;4(4):469-83
pubmed: 21324930
Nat Immunol. 2019 Jan;20(1):29-39
pubmed: 30538339
Hum Gene Ther. 2019 Jul;30(7):893-905
pubmed: 30786776
Circulation. 2017 Mar 7;135(10):e146-e603
pubmed: 28122885
Nat Rev Cardiol. 2018 Aug;15(8):445-456
pubmed: 29748594
Curr Cancer Drug Targets. 2016;16(7):618-30
pubmed: 26881932
J Biol Chem. 1997 Jan 24;272(4):2446-51
pubmed: 8999957
J Am Coll Cardiol. 2006 Jul 4;48(1):15-20
pubmed: 16814643
J Mol Cell Cardiol. 2019 Aug;133:164-173
pubmed: 31194987
Development. 2014 Dec;141(23):4489-99
pubmed: 25406396
Physiol Rev. 2019 Apr 1;99(2):1281-1324
pubmed: 30864875
Am J Physiol Heart Circ Physiol. 2011 Oct;301(4):H1656-66
pubmed: 21666120
NPJ Regen Med. 2016 Jun 09;1:16001
pubmed: 29302333
Front Cardiovasc Med. 2019 Jul 31;6:101
pubmed: 31417911
Nat Neurosci. 2010 Jan;13(1):133-40
pubmed: 20023653
Methods Mol Biol. 2019;1951:59-73
pubmed: 30825144
Am J Physiol Heart Circ Physiol. 2011 Nov;301(5):H1765-80
pubmed: 21873501
J Am Coll Cardiol. 2019 Jan 22;73(2):190-209
pubmed: 30654892
Nature. 1994 Jul 7;370(6484):61-5
pubmed: 8015608
J Exp Med. 2009 Oct 26;206(11):2397-406
pubmed: 19841087
J Biol Chem. 2010 Sep 24;285(39):30316-27
pubmed: 20643648
J Immunol Methods. 2014 Jun;408:89-100
pubmed: 24857755
Cell Host Microbe. 2016 Oct 12;20(4):458-470
pubmed: 27736644
Sci Rep. 2018 Jan 30;8(1):1854
pubmed: 29382844
Am J Pathol. 2012 May;180(5):1863-78
pubmed: 22464947
Basic Res Cardiol. 2019 Aug 15;114(5):37
pubmed: 31418072
Nat Commun. 2016 Jun 24;7:11853
pubmed: 27340017
Circ Res. 2019 Jan 18;124(2):263-278
pubmed: 30582448
FASEB J. 2012 Nov;26(11):4481-94
pubmed: 22859368
Nat Rev Mol Cell Biol. 2007 Mar;8(3):221-33
pubmed: 17318226
Cell Rep. 2018 Apr 10;23(2):622-636
pubmed: 29642017
Sci Rep. 2013;3:2190
pubmed: 23846580
Nat Commun. 2016 Jul 22;7:12260
pubmed: 27447449
Cytometry A. 2004 Dec;62(2):169-73
pubmed: 15536642
Circ Res. 2015 Feb 27;116(5):857-66
pubmed: 25587097
Anal Biochem. 1994 Feb 1;216(2):276-84
pubmed: 8179182
PLoS One. 2010 Jun 11;5(6):e11084
pubmed: 20552031
J Am Coll Cardiol. 2010 Apr 13;55(15):1629-38
pubmed: 20378083
Am J Pathol. 2007 Mar;170(3):818-29
pubmed: 17322368
Compr Physiol. 2015 Sep 20;5(4):1841-75
pubmed: 26426469
Blood. 2009 May 28;113(22):5680-8
pubmed: 19144989
Nat Med. 2007 Aug;13(8):952-61
pubmed: 17660828
EMBO Mol Med. 2020 Feb 7;12(2):e10862
pubmed: 31793743
J Clin Invest. 2014 Jul;124(7):2921-34
pubmed: 24937432
J Exp Med. 2020 Feb 13;217(3):e20190103
pubmed: 32997468
FASEB J. 2019 Feb;33(2):2278-2289
pubmed: 30260706
Nat Rev Cardiol. 2010 Jan;7(1):30-7
pubmed: 19949426
Curr Drug Targets. 2013 Mar;14(3):276-86
pubmed: 23316962
Methods Mol Biol. 2010;633:113-24
pubmed: 20204624
Transgenic Res. 1999 Aug;8(4):265-77
pubmed: 10621974
Cell. 1992 Dec 11;71(6):1003-14
pubmed: 1333888
Circ Res. 2001 Aug 3;89(3):201-10
pubmed: 11485970
Nat Med. 2013 Dec;19(12):1617-24
pubmed: 24216753
J Cell Biol. 2002 Apr 29;157(3):493-507
pubmed: 11970960
EMBO J. 2015 Jul 14;34(14):1875-88
pubmed: 25991604
Oncotarget. 2017 Aug 16;8(41):71024-71037
pubmed: 29050340
Science. 2009 Jul 31;325(5940):612-6
pubmed: 19644120
Circ Res. 2009 Jan 30;104(2):e9-18
pubmed: 19096025
Circ Res. 2016 Feb 5;118(3):400-9
pubmed: 26635390
Dev Dyn. 2018 Sep;247(9):1083-1092
pubmed: 30079980
Histochem Cell Biol. 2009 Apr;131(4):471-81
pubmed: 19030868
Development. 2012 Dec 1;139(23):4449-60
pubmed: 23095891
J Vis Exp. 2009 Oct 14;(32):
pubmed: 19829290

Auteurs

Laura Alonso-Herranz (L)

Myocardial Pathophysiology Area, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
ORCID: 0000-0003-0880-4735

Álvaro Sahún-Español (Á)

Vascular Pathophysiology Area, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
ORCID: 0000-0003-3833-5386

Ana Paredes (A)

Myocardial Pathophysiology Area, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
ORCID: 0000-0003-3119-8788

Pilar Gonzalo (P)

Vascular Pathophysiology Area, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
ORCID: 0000-0001-8811-8369

Polyxeni Gkontra (P)

Vascular Pathophysiology Area, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.

Vanessa Núñez (V)

Myocardial Pathophysiology Area, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.

Cristina Clemente (C)

Vascular Pathophysiology Area, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Molecular Biomedicine Department, Centro de Investigaciones Biológicas Margarita Salas (CIB-CSIC), Madrid, Spain.
ORCID: 0000-0002-5831-9132

Marta Cedenilla (M)

Myocardial Pathophysiology Area, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.

María Villalba-Orero (M)

Myocardial Pathophysiology Area, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.

Javier Inserte (J)

Cardiovascular Diseases Research Group, Vall d'Hebron University Hospital and Research Institute (VHIR), Barcelona, Spain.
CIBER de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.

David García-Dorado (D)

Cardiovascular Diseases Research Group, Vall d'Hebron University Hospital and Research Institute (VHIR), Barcelona, Spain.
CIBER de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.

Alicia G Arroyo (AG)

Vascular Pathophysiology Area, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Molecular Biomedicine Department, Centro de Investigaciones Biológicas Margarita Salas (CIB-CSIC), Madrid, Spain.
ORCID: 0000-0002-1536-3846

Mercedes Ricote (M)

Myocardial Pathophysiology Area, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
ORCID: 0000-0002-8090-8902

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Macrophages promote endothelial-to-mesenchymal...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Scléroprotéines › Protéines de la matrice extracellulaire › Collagène › Macrophages promote endothelial-to-mesenchymal...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Macrophages promote endothelial-to-mesenchymal...
questionsmedicales.fr › Tissus › Épithélium › Endothélium › Endothélium vasculaire › Macrophages promote endothelial-to-mesenchymal...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transdifférenciation cellulaire › Transition épithélio-mésenchymateuse › Macrophages promote endothelial-to-mesenchymal...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Fibrose › Macrophages promote endothelial-to-mesenchymal...
questionsmedicales.fr › Techniques d'investigation › Techniques cytologiques › Cytophotométrie › Cytométrie en flux › Macrophages promote endothelial-to-mesenchymal...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Macrophages promote endothelial-to-mesenchymal...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HEK293 › Macrophages promote endothelial-to-mesenchymal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Macrophages promote endothelial-to-mesenchymal...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Macrophages promote endothelial-to-mesenchymal...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Metalloproteases › Metalloendopeptidases › Matrix metalloproteinases › Matrix metalloproteinase 14 › Macrophages promote endothelial-to-mesenchymal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Macrophages promote endothelial-to-mesenchymal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Macrophages promote endothelial-to-mesenchymal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Macrophages promote endothelial-to-mesenchymal...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Circulation sanguine › Microcirculation › Macrophages promote endothelial-to-mesenchymal...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Nécrose › Infarctus › Infarctus du myocarde › Macrophages promote endothelial-to-mesenchymal...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Macrophages promote endothelial-to-mesenchymal...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Complications postopératoires › Lésion d'ischémie-reperfusion › Macrophages promote endothelial-to-mesenchymal...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines de la superfamille du TGF bêta › Facteur de croissance transformant bêta › Facteur de croissance transformant bêta-1 › Macrophages promote endothelial-to-mesenchymal...
questionsmedicales.fr › Maladies cardiovasculaires › Cardiopathies › Dysfonction ventriculaire › Dysfonction ventriculaire gauche › Macrophages promote endothelial-to-mesenchymal...