Theoretical Studies of the Mechanism of Carbamoylation of Nucleobases by Isocyanates.
Journal
Chemical research in toxicology
ISSN: 1520-5010
Titre abrégé: Chem Res Toxicol
Pays: United States
ID NLM: 8807448
Informations de publication
Date de publication:
16 11 2020
16 11 2020
Historique:
pubmed:
21
10
2020
medline:
24
8
2021
entrez:
20
10
2020
Statut:
ppublish
Résumé
Isocyanates with the -N═C═O functional group are highly reactive compounds. They are used in various industrial applications and have been found as possible metabolites of hydroxamic acids. Isocyanates interact with biopolymers and are notorious mutagens. Mutagenic effects of isocyanates are caused by the formation of covalent adducts with nucleobases of DNA, primarily cytosines, through carbamoylation of NH
Identifiants
pubmed: 33076655
doi: 10.1021/acs.chemrestox.0c00220
doi:
Substances chimiques
Isocyanates
0
DNA
9007-49-2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM