A new sponge-type hydrogel based on hyaluronic acid and poly(methylvinylether-alt-maleic acid) as a 3D platform for tumor cell growth.
Carcinoma, Hepatocellular
/ drug therapy
Cell Cycle
/ drug effects
Cell Proliferation
/ drug effects
Diphenhydramine
/ pharmacology
Hep G2 Cells
Humans
Hyaluronic Acid
/ chemistry
Hydrogel, Polyethylene Glycol Dimethacrylate
/ chemistry
Hydrogels
/ chemistry
Lidocaine
/ pharmacology
Liver Neoplasms
/ drug therapy
Maleates
/ chemistry
Propranolol
/ pharmacology
3D tumor surrogate
Cell growth
Hyaluronic acid
Hydrogel scaffolds
Sponge-type hydrogel
Tissue engineering
Journal
International journal of biological macromolecules
ISSN: 1879-0003
Titre abrégé: Int J Biol Macromol
Pays: Netherlands
ID NLM: 7909578
Informations de publication
Date de publication:
15 Dec 2020
15 Dec 2020
Historique:
received:
24
07
2020
revised:
29
09
2020
accepted:
13
10
2020
pubmed:
26
10
2020
medline:
7
4
2021
entrez:
25
10
2020
Statut:
ppublish
Résumé
A new sponge-type hydrogel was obtained by cross-linking hyaluronic acid (HA) and poly(methylvinylether-alt-maleic acid) P(MVE-alt-MA) through a solvent-free thermal method. The sponge-type hydrogel was characterized and checked as a support for cell growth. The influence of concentration and weight ratio of polymers on the morphology and hydrogel stability was investigated. The total polymers concentration of 3% (w/w) and the weight ratio of 1:1 were optimal for the synthesis of a stable hydrogel (HA
Identifiants
pubmed: 33098901
pii: S0141-8130(20)34726-7
doi: 10.1016/j.ijbiomac.2020.10.095
pii:
doi:
Substances chimiques
Hydrogels
0
Maleates
0
Hydrogel, Polyethylene Glycol Dimethacrylate
25852-47-5
Diphenhydramine
8GTS82S83M
Hyaluronic Acid
9004-61-9
maleic acid
91XW058U2C
Lidocaine
98PI200987
Propranolol
9Y8NXQ24VQ
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2528-2540Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.