Protein Delivery by Peptide-Based Stealth Liposomes: A Biomolecular Insight into Enzyme Replacement Therapy.

Cells, Cultured Drug Compounding / methods Drug Liberation Enzyme Assays Enzyme Replacement Therapy / methods Fibroblasts Humans Liposomes Membrane Proteins / administration & dosage Nanoparticles / chemistry Neuronal Ceroid-Lipofuscinoses / drug therapy Peptides / chemistry Primary Cell Culture Thiolester Hydrolases / administration & dosage
blood brain barrier (BBB) enzyme replacement therapy (ERT) liposomes lysosomal storage disorders (LSDs) peptide aptamers

Journal

Molecular pharmaceutics
ISSN: 1543-8392
Titre abrégé: Mol Pharm
Pays: United States
ID NLM: 101197791

Informations de publication

Date de publication:
07 12 2020
Historique:
pubmed: 29 10 2020
medline: 18 9 2021
entrez: 28 10 2020
Statut: ppublish

Résumé

Infantile neural ceroid lipofuscinosis (INCL) is a lysosomal storage disorder characterized by mutations in the

Identifiants

DOI: 10.1021/acs.molpharmaceut.0c00615 PMID: 33112630
pubmed: 33112630
doi: 10.1021/acs.molpharmaceut.0c00615
doi:

Substances chimiques

Liposomes 0
Membrane Proteins 0
Peptides 0
Thiolester Hydrolases EC 3.1.2.-
PPT1 protein, human EC 3.1.2.22

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

4510-4521

Auteurs

Melissa Santi (M)

Center for Nanotechnology Innovation@NEST, Istituto Italiano di Tecnologia, Pisa 56127, Italy.
NEST, Scuola Normale Superiore and Istituto Nanoscienze-CNR, Pisa 56127, Italy.
ORCID: 0000-0002-9374-883X

Francesco Finamore (F)

Institute of Clinical Physiology-CNR, Pisa 56127, Italy.

Antonella Cecchettini (A)

University of Pisa, Dept. of Clinical and Experimental Medicine, Pisa 56126, Italy.

Filippo Maria Santorelli (FM)

Molecular Medicine, IRCCS Stella Maris, Pisa 56128, Italy.

Stefano Doccini (S)

Molecular Medicine, IRCCS Stella Maris, Pisa 56128, Italy.

Silvia Rocchiccioli (S)

Institute of Clinical Physiology-CNR, Pisa 56127, Italy.

Giovanni Signore (G)

NEST, Scuola Normale Superiore and Istituto Nanoscienze-CNR, Pisa 56127, Italy.
Fondazione Pisana per la Scienza, Pisa 56017, Italy.

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Classifications MeSH

questionsmedicales.fr › Cellules › Cellules cultivées › Protein Delivery by Peptide-Based Stealth...
questionsmedicales.fr › Techniques d'investigation › Préparation de médicament › Protein Delivery by Peptide-Based Stealth...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Libération de médicament › Protein Delivery by Peptide-Based Stealth...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Dosages enzymatiques › Protein Delivery by Peptide-Based Stealth...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Thérapie enzymatique › Thérapie enzymatique substitutive › Protein Delivery by Peptide-Based Stealth...
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Fibroblastes › Protein Delivery by Peptide-Based Stealth...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Protein Delivery by Peptide-Based Stealth...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomimétiques › Membrane artificielle › Liposomes › Protein Delivery by Peptide-Based Stealth...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protein Delivery by Peptide-Based Stealth...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › Protein Delivery by Peptide-Based Stealth...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Erreurs innées du métabolisme › Erreurs innées du métabolisme lipidique › Lipidoses › Céroïdes-lipofuscinoses neuronales › Protein Delivery by Peptide-Based Stealth...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Protein Delivery by Peptide-Based Stealth...
questionsmedicales.fr › Techniques d'investigation › Techniques in vitro › Techniques de culture › Techniques de culture cellulaire › Culture de cellules primaires › Protein Delivery by Peptide-Based Stealth...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Thiolester hydrolases › Protein Delivery by Peptide-Based Stealth...