Xrn1 influence on gene transcription results from the combination of general effects on elongating RNA pol II and gene-specific chromatin configuration.
3ʹ pre-mRNA processing
Transcription elongation
Xrn1
mRNA buffering
mRNA decay
mRNA decay/gene transcription crosstalk
Journal
RNA biology
ISSN: 1555-8584
Titre abrégé: RNA Biol
Pays: United States
ID NLM: 101235328
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
pubmed:
4
11
2020
medline:
18
1
2022
entrez:
3
11
2020
Statut:
ppublish
Résumé
mRNA homoeostasis is favoured by crosstalk between transcription and degradation machineries. Both the Ccr4-Not and the Xrn1-decaysome complexes have been described to influence transcription. While Ccr4-Not has been shown to directly stimulate transcription elongation, the information available on how Xrn1 influences transcription is scarce and contradictory. In this study we have addressed this issue by mapping RNA polymerase II (RNA pol II) at high resolution, using CRAC and BioGRO-seq techniques in
Identifiants
pubmed: 33138675
doi: 10.1080/15476286.2020.1845504
pmc: PMC8354610
doi:
Substances chimiques
Chromatin
0
Nucleosomes
0
Saccharomyces cerevisiae Proteins
0
Transcriptional Elongation Factors
0
RNA Polymerase II
EC 2.7.7.-
Exoribonucleases
EC 3.1.-
XRN1 protein, S cerevisiae
EC 3.1.11.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1310-1323Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM124446
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM126557
Pays : United States
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