Five millennia of Bartonella quintana bacteraemia.
Bacteremia
/ diagnosis
Bartonella quintana
/ genetics
DNA, Bacterial
/ genetics
Dental Pulp
/ microbiology
Europe
/ epidemiology
Fossils
/ microbiology
Humans
Military Personnel
Paleodontology
/ methods
Prevalence
Real-Time Polymerase Chain Reaction
Sequence Analysis, DNA
Tooth
/ microbiology
Trench Fever
/ diagnosis
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2020
2020
Historique:
received:
15
03
2020
accepted:
09
09
2020
entrez:
4
11
2020
pubmed:
5
11
2020
medline:
29
12
2020
Statut:
epublish
Résumé
During the two World Wars, Bartonella quintana was responsible for trench fever and is now recognised as an agent of re-emerging infection. Many reports have indicated widespread B. quintana exposure since the 1990s. In order to evaluate its prevalence in ancient populations, we used real-time PCR to detect B. quintana DNA in 400 teeth collected from 145 individuals dating from the 1st to 19th centuries in nine archaeological sites, with the presence of negative controls. Fisher's exact test was used to compare the prevalence of B. quintana in civil and military populations. B. quintana DNA was confirmed in a total of 28/145 (19.3%) individuals, comprising 78 citizens and 67 soldiers, 20.1% and 17.9% of which were positive for B. quintana bacteraemia, respectively. This study analysed previous studies on these ancient samples and showed that the presence of B. quintana infection followed the course of time in human history; a total of 14/15 sites from five European countries had a positive prevalence. The positive rate in soldiers was higher than those of civilians, with 20% and 18.8%, respectively, in the 18th and 19th centuries, but the difference in frequency was not significant. These results confirmed the role of dental pulp in diagnosing B. quintana bacteraemia in ancient populations and showed the incidence of B. quintana in both civilians and soldiers.
Identifiants
pubmed: 33147255
doi: 10.1371/journal.pone.0239526
pii: PONE-D-20-07460
pmc: PMC7641340
doi:
Substances chimiques
DNA, Bacterial
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0239526Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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