Antimicrobial activity of amphiphilic nanomicelles loaded with curcumin against Pseudomonas aeruginosa alone and activated by blue laser light.

Anti-Infective Agents Curcumin / pharmacology Lasers Photochemotherapy Photosensitizing Agents Pseudomonas aeruginosa
antimicrobial blue laser curcumin nanomicelles photodynamic therapy

Journal

Journal of biophotonics
ISSN: 1864-0648
Titre abrégé: J Biophotonics
Pays: Germany
ID NLM: 101318567

Informations de publication

Date de publication:
03 2021
Historique:
received: 01 09 2020
revised: 30 10 2020
accepted: 04 11 2020
pubmed: 6 11 2020
medline: 13 7 2021
entrez: 5 11 2020
Statut: ppublish

Résumé

The aim of this work was to assess the antimicrobial efficacy on Pseudomonas aeruginosa of nanomicelles loaded with curcumin (CUR) alone and activated by blue laser light in an antimicrobial photodynamic therapy (APDT) approach. First, free CUR in liquid suspension and loaded in three amphiphilic nanomicelles (CUR-DAPMA, CUR-SPD and CUR-SPM) were tested both on bacteria and keratinocytes. While free CUR exerted limited efficacy showing moderate cytotoxicity, a strong inhibition of bacterial growth was obtained using all three nanosystems without toxicity on eukaryotic cells. CUR-SPM emerged as the most effective, and was therefore employed in APDT experiments. Among the three sublethal blue laser (λ 445 nm) protocols tested, the ones characterized by a fluence of 18 and 30 J/cm

Identifiants

DOI: 10.1002/jbio.202000350 PMID: 33151640
pubmed: 33151640
doi: 10.1002/jbio.202000350
doi:

Substances chimiques

Anti-Infective Agents 0
Photosensitizing Agents 0
Curcumin IT942ZTH98

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e202000350

Informations de copyright

© 2020 Wiley-VCH GmbH.

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Auteurs

Katia Rupel (K)

Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
ORCID: 0000-0002-6150-9439

Luisa Zupin (L)

Institute for Maternal and Child Health, IRCCS Materno Infantile Burlo Garofolo, Trieste, Italy.
ORCID: 0000-0001-5886-9129

Silvia Brich (S)

Laboratory of Molecular Pathology, Department of Pathology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

Mario Mardirossian (M)

Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.

Giulia Ottaviani (G)

Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.

Margherita Gobbo (M)

Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.

Roberto Di Lenarda (R)

Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.

Sabrina Pricl (S)

Molecular Biology and Nanotechnology Laboratory (MolBNL@UniTS), DEA, University of Trieste, Trieste, Italy.
Department of General Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, Lodz, Poland.

Sergio Crovella (S)

Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
Department of Biological and Environmental Sciences, College of Arts and Sciences, University of Qatar, Doha, Qatar.

Serena Zacchigna (S)

Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
Cardiovascular Biology Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy.

Matteo Biasotto (M)

Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antimicrobial activity of amphiphilic...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Diarylheptanoïdes › Curcumine › Antimicrobial activity of amphiphilic...
questionsmedicales.fr › Équipement et fournitures › Équipement et fournitures pour les applications des radiations › Lasers › Antimicrobial activity of amphiphilic...
questionsmedicales.fr › Thérapeutique › Photothérapie › Photothérapie dynamique › Antimicrobial activity of amphiphilic...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Radiosensibilisants › Photosensibilisants › Antimicrobial activity of amphiphilic...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Pseudomonadaceae › Pseudomonas › Pseudomonas aeruginosa › Antimicrobial activity of amphiphilic...