Rapid classification and identification of chemical constituents in Epimedium koreanum Nakai by UPLC-Q-TOF-MS combined with data post-processing techniques.
Epimedium koreanum Nakai
UPLC-Q-TOF-MS
characteristic fragmentations
fragmentation pathway
neutral losses
Journal
Phytochemical analysis : PCA
ISSN: 1099-1565
Titre abrégé: Phytochem Anal
Pays: England
ID NLM: 9200492
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
revised:
24
09
2020
received:
06
07
2020
accepted:
26
09
2020
pubmed:
10
11
2020
medline:
4
6
2021
entrez:
9
11
2020
Statut:
ppublish
Résumé
Epimedium koreanum Nakai (EKN), is a well-known Chinese herbal medicine for the treatment of osteoporosis, immunosuppression, tumours and cardiovascular diseases. Comprehensive component identification is essential for elucidation of its pharmacological mechanism and quality control. However, its complex chemical composition has caused certain difficulties in the analysis of this traditional Chinese medicine (TCM). Therefore, there is an urgent need to establish a method for rapid classification and identification of EKN chemical components. To establish a method for rapid classification and identification of the main components of flavonoids, organic acids and alkaloids in EKN. The samples were analysed by ultra-high-performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) and data post-processing techniques. The UPLC system used a BEH C Finally, we successfully screened out 51 chemical components, including 40 flavonoids, nine organic acids, and two alkaloids. The established method not only comprehensively analysed the chemical compositions of EKN, solved the difficult problems of analysis and identification of the complex chemical compositions of the TCM, but also further promoted the development of the application of chemical compositions of TCM.
Substances chimiques
Drugs, Chinese Herbal
0
Flavonoids
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
575-591Subventions
Organisme : National Natural Science Foundation of China
ID : 81873194
Organisme : National Natural Science Foundation of China
ID : 82004093
Informations de copyright
© 2020 John Wiley & Sons, Ltd.
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