Decoding myofibroblast origins in human kidney fibrosis.

Adaptor Proteins, Signal Transducing / metabolism Animals Calcium-Binding Proteins / metabolism Case-Control Studies Cell Differentiation Cell Lineage Extracellular Matrix / metabolism Female Fibroblasts / cytology Fibrosis / pathology Humans Kidney Tubules / pathology Male Mesoderm / cytology Mice Myofibroblasts / metabolism Pericytes / cytology RNA-Seq Receptor, Platelet-Derived Growth Factor alpha / metabolism Receptor, Platelet-Derived Growth Factor beta / metabolism Renal Insufficiency, Chronic / pathology Single-Cell Analysis Transcriptome

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
01 2021
Historique:
received: 30 01 2020
accepted: 19 10 2020
pubmed: 12 11 2020
medline: 26 2 2021
entrez: 11 11 2020
Statut: ppublish

Résumé

Kidney fibrosis is the hallmark of chronic kidney disease progression; however, at present no antifibrotic therapies exist

Identifiants

DOI: 10.1038/s41586-020-2941-1 PMID: 33176333 PMC: PMC7611626
pubmed: 33176333
doi: 10.1038/s41586-020-2941-1
pii: 10.1038/s41586-020-2941-1
pmc: PMC7611626
mid: EMS114558
doi:

Substances chimiques

Adaptor Proteins, Signal Transducing 0
Calcium-Binding Proteins 0
NKD2 protein, human 0
Receptor, Platelet-Derived Growth Factor alpha EC 2.7.10.1
Receptor, Platelet-Derived Growth Factor beta EC 2.7.10.1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

281-286

Subventions

Organisme : Wellcome Trust
ID : 104366/Z/14/Z
Pays : United Kingdom
Organisme : Medical Research Council
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 219542/Z/19/Z
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : European Research Council
ID : 677448
Pays : International

Commentaires et corrections

Type : CommentIn
Type : CommentIn
Type : CommentIn

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Auteurs

Christoph Kuppe (C)

Division of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany.
Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany.
ORCID: 0000-0003-4597-9833

Mahmoud M Ibrahim (MM)

Division of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany.
Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany.
Bayer Pharma AG, Berlin, Germany.
ORCID: 0000-0001-6954-5314

Jennifer Kranz (J)

Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany.
Department of Urology and Paediatric Urology, St Antonius Hospital, Eschweiler, Germany.
Department of Urology, Kidney Transplantation Centre, Martin-Luther-University, Halle, Germany.

Xiaoting Zhang (X)

Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany.

Susanne Ziegler (S)

Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany.

Javier Perales-Patón (J)

Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany.
Institute for Computational Biomedicine, Faculty of Medicine, Heidelberg University and Heidelberg University Hospital, BioQuant, Heidelberg, Germany.
Joint Research Center for Computational Biomedicine, RWTH Aachen University Hospital, Aachen, Germany.
ORCID: 0000-0003-0780-6683

Jitske Jansen (J)

Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany.
Department of Pathology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Department of Pediatric Nephrology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Amalia Children's Hospital, Nijmegen, The Netherlands.

Katharina C Reimer (KC)

Division of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany.
Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany.
Department of Cell Biology, Institute for Biomedical Technologies, RWTH Aachen University, Aachen, Germany.
ORCID: 0000-0002-7118-9133

James R Smith (JR)

Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.

Ross Dobie (R)

Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.

John R Wilson-Kanamori (JR)

Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.
ORCID: 0000-0002-1372-9912

Maurice Halder (M)

Division of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany.
Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany.
ORCID: 0000-0003-2386-9684

Yaoxian Xu (Y)

Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany.

Nazanin Kabgani (N)

Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany.

Nadine Kaesler (N)

Division of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany.
Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany.

Martin Klaus (M)

III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
ORCID: 0000-0003-0880-3302

Lukas Gernhold (L)

III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Victor G Puelles (VG)

III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Department of Anatomy and Developmental Biology, Monash Biomedical Discovery Institute, Monash University, Melbourne, Victoria, Australia.
ORCID: 0000-0002-7735-5462

Tobias B Huber (TB)

III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Peter Boor (P)

Division of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany.
Department of Pathology, RWTH Aachen University, Aachen, Germany.
ORCID: 0000-0001-9921-4284

Sylvia Menzel (S)

Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany.

Remco M Hoogenboezem (RM)

Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.

Eric M J Bindels (EMJ)

Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.

Joachim Steffens (J)

Department of Urology and Paediatric Urology, St Antonius Hospital, Eschweiler, Germany.

Jürgen Floege (J)

Division of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany.

Rebekka K Schneider (RK)

Department of Cell Biology, Institute for Biomedical Technologies, RWTH Aachen University, Aachen, Germany.
Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.

Julio Saez-Rodriguez (J)

Institute for Computational Biomedicine, Faculty of Medicine, Heidelberg University and Heidelberg University Hospital, BioQuant, Heidelberg, Germany.
Joint Research Center for Computational Biomedicine, RWTH Aachen University Hospital, Aachen, Germany.
Molecular Medicine Partnership Unit, European Molecular Biology Laboratory, Heidelberg University, Heidelberg, Germany.
ORCID: 0000-0002-8552-8976

Neil C Henderson (NC)

Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.
MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
ORCID: 0000-0002-2273-4094

Rafael Kramann (R)

Division of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany. rkramann@gmx.net.
Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany. rkramann@gmx.net.
Department of Internal Medicine, Nephrology and Transplantation, Erasmus Medical Center, Rotterdam, The Netherlands. rkramann@gmx.net.
ORCID: 0000-0003-4048-6351

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines adaptatrices de la transduction du signal › Decoding myofibroblast origins in human kidney...
questionsmedicales.fr › Eucaryotes › Animaux › Decoding myofibroblast origins in human kidney...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › Protéines de liaison au calcium › Decoding myofibroblast origins in human kidney...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › Decoding myofibroblast origins in human kidney...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Decoding myofibroblast origins in human kidney...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Développement embryonnaire et foetal › Développement embryonnaire › Lignage cellulaire › Decoding myofibroblast origins in human kidney...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace extracellulaire › Matrice extracellulaire › Decoding myofibroblast origins in human kidney...
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Fibroblastes › Decoding myofibroblast origins in human kidney...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Fibrose › Decoding myofibroblast origins in human kidney...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Decoding myofibroblast origins in human kidney...
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