Review of Genetic Variation as a Predictive Biomarker for Chronic Graft-Versus-Host-Disease After Allogeneic Stem Cell Transplantation.
Animals
Chronic Disease
Genetic Markers
Genetic Predisposition to Disease
Graft vs Host Disease
/ diagnosis
HLA Antigens
/ genetics
Hematopoietic Stem Cell Transplantation
/ adverse effects
Histocompatibility
/ genetics
Humans
Immunosuppressive Agents
/ therapeutic use
Pharmacogenomic Variants
Polymorphism, Single Nucleotide
Risk Assessment
Risk Factors
Transplantation, Homologous
/ adverse effects
Treatment Outcome
biomarkers
gene marker
genetic screen
graft versus host disease (GvHD)
stem cell transplantation (HSCT)
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
23
06
2020
accepted:
28
09
2020
entrez:
16
11
2020
pubmed:
17
11
2020
medline:
16
6
2021
Statut:
epublish
Résumé
Chronic graft-versus-host disease (cGvHD) is one of the major complications of allogeneic stem cell transplantation (HSCT). cGvHD is an autoimmune-like disorder affecting multiple organs and involves a dermatological rash, tissue inflammation and fibrosis. The incidence of cGvHD has been reported to be as high as 30% to 60% and there are currently no reliable tools for predicting the occurrence of cGvHD. There is therefore an important unmet clinical need for predictive biomarkers. The present review summarizes the state of the art for genetic variation as a predictive biomarker for cGvHD. We discuss three different modes of action for genetic variation in transplantation: genetic associations, genetic matching, and pharmacogenetics. The results indicate that currently, there are no genetic polymorphisms or genetic tools that can be reliably used as validated biomarkers for predicting cGvHD. A number of recommendations for future studies can be drawn. The majority of studies to date have been under-powered and included too few patients and genetic markers. Like in all complex multifactorial diseases, large collaborative genome-level studies are now needed to achieve reliable and unbiased results. Some of the candidate genes, in particular,
Identifiants
pubmed: 33193367
doi: 10.3389/fimmu.2020.575492
pmc: PMC7604383
doi:
Substances chimiques
Genetic Markers
0
HLA Antigens
0
Immunosuppressive Agents
0
Types de publication
Research Support, Non-U.S. Gov't
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
575492Informations de copyright
Copyright © 2020 Partanen, Hyvärinen, Bickeböller, Bogunia-Kubik, Crossland, Ivanova, Perutelli and Dressel.
Références
Blood. 2017 Aug 31;130(9):1089-1096
pubmed: 28667011
Biol Blood Marrow Transplant. 2010 Apr;16(4):533-42
pubmed: 19961944
Blood. 2016 Jan 14;127(2):260-7
pubmed: 26527675
Int J Mol Sci. 2015 Aug 10;16(8):18601-27
pubmed: 26266406
Biomed Rep. 2017 Jun;6(6):698-702
pubmed: 28584644
Semin Hematol. 2019 Jul;56(3):194-200
pubmed: 31202430
J Neuroinflammation. 2012 Oct 10;9:235
pubmed: 23050663
Blood. 2016 Oct 13;128(15):1979-1986
pubmed: 27549307
Sci Rep. 2015 Jun 11;5:11098
pubmed: 26067905
Bone Marrow Transplant. 2009 Jul;44(2):97-103
pubmed: 19169284
Immunol Rev. 1997 Feb;155:165-74
pubmed: 9059892
Nat Genet. 2013 Oct;45(10):1238-1243
pubmed: 24013639
Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4778-83
pubmed: 10781084
Biol Blood Marrow Transplant. 2013 Aug;19(8):1244-53
pubmed: 23756210
J Cell Biochem. 2017 Dec;118(12):4872-4880
pubmed: 28543357
Clin Exp Immunol. 2002 Mar;127(3):553-9
pubmed: 11966775
Am J Hum Genet. 1997 Feb;60(2):397-407
pubmed: 9012413
Int J Immunogenet. 2018 Jul 25;:
pubmed: 30043490
PLoS Comput Biol. 2016 Sep 29;12(9):e1005088
pubmed: 27684477
Bone Marrow Transplant. 2017 May;52(5):739-744
pubmed: 28134923
F1000Res. 2018 Sep 19;7:
pubmed: 30338057
Cytokine. 2016 Feb;78:37-43
pubmed: 26618233
Biol Blood Marrow Transplant. 2006 Aug;12(8):876-84
pubmed: 16864058
Cancer. 2017 Sep 1;123(17):3346-3355
pubmed: 28452054
Transplantation. 2008 Jun 27;85(12):1809-16
pubmed: 18580475
Blood Adv. 2018 Jul 24;2(14):1719-1737
pubmed: 30030270
Blood. 2017 Feb 9;129(6):791-798
pubmed: 27872059
Blood. 2003 Aug 1;102(3):814-9
pubmed: 12689936
Biol Blood Marrow Transplant. 2018 Sep;24(9):1802-1807
pubmed: 29656138
Hum Immunol. 2011 Feb;72(2):139-43
pubmed: 21081144
Scand J Immunol. 2013 Aug;78(2):214-20
pubmed: 23692589
Biol Blood Marrow Transplant. 2007 Mar;13(3):315-28
pubmed: 17317585
Blood. 2016 Dec 29;128(26):3169-3176
pubmed: 27811019
Eur J Haematol. 2009 Oct;83(4):343-56
pubmed: 19500138
Blood. 2015 Feb 12;125(7):1189-97
pubmed: 25519752
Sci Rep. 2017 Nov 15;7(1):15666
pubmed: 29142307
Front Immunol. 2020 Feb 03;11:19
pubmed: 32117222
Blood. 2012 Oct 4;120(14):2796-806
pubmed: 22859606
Methods Mol Biol. 2018;1709:371-396
pubmed: 29177673
Genet Epidemiol. 2019 Mar;43(2):122-136
pubmed: 30604442
Nature. 1999 Oct 28;401(6756):921-3
pubmed: 10553908
Blood. 2016 Nov 17;128(20):2450-2456
pubmed: 27758874
Blood. 2014 Dec 18;124(26):3996-4003
pubmed: 25323824
Hum Hered. 2013;76(2):64-75
pubmed: 24434848
Cell Stress Chaperones. 2001 Jul;6(3):282-95
pubmed: 11599570
Blood. 2010 Oct 7;116(14):2411-9
pubmed: 20581313
J Cancer Res Clin Oncol. 2018 Aug;144(8):1423-1434
pubmed: 29802455
Transplantation. 2005 Apr 15;79(7):815-20
pubmed: 15818324
Front Immunol. 2019 Jul 16;10:1625
pubmed: 31379830
PLoS One. 2017 Sep 25;12(9):e0185213
pubmed: 28945764
Blood. 2002 Nov 15;100(10):3825-7
pubmed: 12393440
Transpl Immunol. 2015 Jun;32(3):188-94
pubmed: 25680846
Bone Marrow Transplant. 2015 Nov;50(11):1445-52
pubmed: 26214138
Annu Rev Genomics Hum Genet. 2013;14:301-23
pubmed: 23875801
Biol Blood Marrow Transplant. 2010 Feb;16(2):239-52
pubmed: 19819342
Sci Transl Med. 2012 Jul 25;4(144):144ra101
pubmed: 22837536
J Virol. 2012 Jun;86(12):6979-85
pubmed: 22496224
Br J Haematol. 2003 Sep;122(5):778-87
pubmed: 12930389
Blood. 2005 Apr 1;105(7):2973-8
pubmed: 15613541
Blood. 2013 Mar 7;121(10):1896-905
pubmed: 23305741
Blood. 2009 Jan 15;113(3):726-32
pubmed: 18945962
Br J Haematol. 2002 Dec;119(4):1133-6
pubmed: 12472598
Haematologica. 2016 Oct;101(10):1260-1266
pubmed: 27354023
Leukemia. 2019 Jan;33(1):240-248
pubmed: 30089915
Ann Hematol. 2018 Jun;97(6):1027-1039
pubmed: 29549412
Science. 2002 Mar 15;295(5562):2097-100
pubmed: 11896281
Bone Marrow Transplant. 2017 Jan;52(1):95-100
pubmed: 27595289
Blood. 2015 Dec 17;126(25):2752-63
pubmed: 26432889
Blood. 2010 Apr 15;115(15):3162-5
pubmed: 20124216
Biol Blood Marrow Transplant. 2015 Sep;21(9):1589-96
pubmed: 25960307
Hum Immunol. 2017 Feb;78(2):95-102
pubmed: 27998801
Annu Rev Immunol. 2018 Apr 26;36:519-548
pubmed: 29394121
Tissue Antigens. 2005 Jun;65(6):519-28
pubmed: 15896199
Hum Immunol. 2000 Jan;61(1):1-6
pubmed: 10658972
Transpl Immunol. 2018 Oct;50:48-54
pubmed: 29906586
Tissue Antigens. 2012 Apr;79(4):287-90
pubmed: 22256791
Transplantation. 2004 Feb 27;77(4):587-96
pubmed: 15084940
Clin Pharmacokinet. 2016 May;55(5):525-50
pubmed: 26563168
Bone Marrow Transplant. 2000 Dec;26(12):1317-23
pubmed: 11223972
Swiss Med Wkly. 2013 Jan 08;143:w13717
pubmed: 23299929
PLoS One. 2016 Jun 24;11(6):e0158242
pubmed: 27341514
Comput Math Methods Med. 2017;2017:6742763
pubmed: 28785300
Arch Immunol Ther Exp (Warsz). 2011 Oct;59(5):353-67
pubmed: 21800130
N Engl J Med. 2019 May 16;380(20):1918-1928
pubmed: 31091373
Eur J Haematol. 2007 Apr;78(4):338-46
pubmed: 17378893
Clin Pharmacokinet. 2016 May;55(5):551-93
pubmed: 26620047
Nature. 2005 Aug 25;436(7054):1186-90
pubmed: 15995699
Biol Blood Marrow Transplant. 2019 May;25(5):949-954
pubmed: 30594542
Nat Neurosci. 2015 Feb;18(2):199-209
pubmed: 25599223
Bone Marrow Transplant. 2014 Mar;49(3):324-31
pubmed: 23872737
Blood Adv. 2020 Jul 28;4(14):3224-3233
pubmed: 32687560
Blood. 2016 Sep 15;128(11):1516-24
pubmed: 27313329
Int J Biol Macromol. 2018 Feb;107(Pt B):2113-2121
pubmed: 29042282
Int J Immunogenet. 2013 Dec;40(6):495-501
pubmed: 23480177
Biol Blood Marrow Transplant. 2018 Mar;24(3):549-554
pubmed: 29247781
Br J Haematol. 2017 Sep;178(5):661-675
pubmed: 28444735
Am J Hematol. 2013 Oct;88(10):883-9
pubmed: 23813863
Hum Immunol. 2017 Nov;78(11-12):672-683
pubmed: 28987962
Leukemia. 2016 Jun;30(6):1344-54
pubmed: 26857467
Blood. 2001 Sep 1;98(5):1594-600
pubmed: 11520812
Int J Clin Exp Pathol. 2015 Mar 01;8(3):3127-31
pubmed: 26045828
Immunity. 1997 Dec;7(6):753-63
pubmed: 9430221
Science. 2013 Apr 5;340(6128):87-91
pubmed: 23559252
Haematologica. 2005 Mar;90(3):425-6
pubmed: 15749687
Cytokine. 2005 Nov 3;32(3-4):171-7
pubmed: 16243534
Biol Blood Marrow Transplant. 2006 Aug;12(8):828-36
pubmed: 16864053
Blood. 2011 Jul 28;118(4):1140-4
pubmed: 21628416
Blood Adv. 2018 Jul 24;2(14):1773-1783
pubmed: 30042143
Biol Blood Marrow Transplant. 2006 Sep;12(9):973-80
pubmed: 16920564
Bone Marrow Transplant. 2010 Feb;45(2):363-9
pubmed: 19525985
EMBO Mol Med. 2015 Oct 19;7(11):1480-502
pubmed: 26483398
Transplantation. 2003 Sep 15;76(5):849-53
pubmed: 14501866
Annu Rev Immunol. 2013;31:413-41
pubmed: 23298206
Scand J Immunol. 2007 Dec;66(6):703-10
pubmed: 18021367
Hum Immunol. 2002 Feb;63(2):139-42
pubmed: 11821161
Genome Res. 2017 May;27(5):813-823
pubmed: 28360230
Hum Immunol. 2018 Jun;79(6):403-412
pubmed: 29605688
Int J Immunogenet. 2006 Oct;33(5):375-84
pubmed: 16984283
Sci Transl Med. 2011 Dec 14;3(113):113ra124
pubmed: 22133594
N Engl J Med. 2015 Aug 13;373(7):599-609
pubmed: 26267621
Nat Rev Genet. 2016 Apr 12;17(6):353-64
pubmed: 27070863
Transplantation. 2006 Oct 27;82(8):1116-7
pubmed: 17060867
Cytokine. 2011 Mar;53(3):306-10
pubmed: 21169032
Clin Immunol Immunopathol. 1995 May;75(2):147-53
pubmed: 7704972
Transpl Immunol. 2016 May;36:25-31
pubmed: 27020764
Nat Rev Genet. 2014 May;15(5):335-46
pubmed: 24739678
J Immunol. 2017 Dec 1;199(11):3892-3899
pubmed: 29055006
Nat Genet. 2018 Sep;50(9):1219-1224
pubmed: 30104762
Cytokine. 2018 Oct;110:404-411
pubmed: 29801972
Genome Res. 2004 Jun;14(6):1176-87
pubmed: 15140828
Blood. 2018 May 31;131(22):2490-2499
pubmed: 29610366
Sci Rep. 2017 Oct 12;7(1):13097
pubmed: 29026154
J Invest Dermatol. 2002 Jan;118(1):155-63
pubmed: 11851889
Biol Blood Marrow Transplant. 2015 Mar;21(3):389-401.e1
pubmed: 25529383
Transplantation. 2006 Oct 27;82(8):1024-30
pubmed: 17060849
Immunogenetics. 2001 May-Jun;53(4):279-87
pubmed: 11491531
Blood. 2013 Sep 12;122(11):1863-72
pubmed: 23878143
Nat Genet. 2009 Dec;41(12):1341-4
pubmed: 19935662
Transplantation. 2003 Dec 27;76(12):1742-9
pubmed: 14688526
Immunogenetics. 2016 Feb;68(2):109-23
pubmed: 26585323
Immunogenetics. 1990;32(4):242-51
pubmed: 1700760
Front Immunol. 2016 Dec 12;7:588
pubmed: 28018354
Blood. 2005 Jun 15;105(12):4878-84
pubmed: 15731175
Eur J Immunol. 2015 Dec;45(12):3454-63
pubmed: 26399450
Bone Marrow Transplant. 2014 May;49(5):649-56
pubmed: 24583628
Nat Med. 2001 Jul;7(7):789-94
pubmed: 11433342
Nature. 2011 Apr 28;472(7344):495-8
pubmed: 21499264
Cytokine. 2013 Feb;61(2):676-81
pubmed: 23317877
Leukemia. 2019 Jan;33(1):230-239
pubmed: 29907809
Blood. 2009 Dec 10;114(25):5216-24
pubmed: 19786616
Sci Rep. 2018 Mar 29;8(1):5396
pubmed: 29599509
Blood. 2012 Apr 26;119(17):3908-16
pubmed: 22327226
Immunogenetics. 2000 Apr;51(4-5):268-80
pubmed: 10803839
Lancet Haematol. 2015 Mar;2(3):e91-100
pubmed: 26687803
Biol Blood Marrow Transplant. 2017 Mar;23(3):436-444
pubmed: 27987385
Mediators Inflamm. 2014;2014:571231
pubmed: 25136146
Scand J Immunol. 2013 Aug;78(2):120-9
pubmed: 23679194
Bone Marrow Transplant. 2011 Feb;46(2):238-43
pubmed: 20400988
Front Immunol. 2018 Feb 02;9:109
pubmed: 29456530
Clin Immunol Immunopathol. 1998 Mar;86(3):252-8
pubmed: 9557158
Bull Exp Biol Med. 2012 May;153(1):68-71
pubmed: 22808497
Proc Natl Acad Sci U S A. 1996 Oct 29;93(22):12445-50
pubmed: 8901601