AhR activation attenuates calcium oxalate nephrocalcinosis by diminishing M1 macrophage polarization and promoting M2 macrophage polarization.
3' Untranslated Regions
/ genetics
Animals
Basic Helix-Loop-Helix Transcription Factors
/ agonists
Calcium Oxalate
/ metabolism
Carbazoles
/ administration & dosage
Case-Control Studies
Cells, Cultured
Computational Biology
Disease Models, Animal
Epithelial Cells
Glyoxylates
/ administration & dosage
Humans
Hypoxia-Inducible Factor 1, alpha Subunit
/ genetics
Interferon Regulatory Factor-1
/ genetics
Kidney
/ diagnostic imaging
Macrophage Activation
Macrophages
/ immunology
Male
Mice
MicroRNAs
/ genetics
Nephrocalcinosis
/ chemically induced
Nephrolithotomy, Percutaneous
Positron Emission Tomography Computed Tomography
Primary Cell Culture
Receptors, Aryl Hydrocarbon
/ agonists
Transcriptional Activation
/ immunology
Up-Regulation
/ immunology
AhR
HIF-1α
IRF1
Macrophage
Nephrocalcinosis
Journal
Theranostics
ISSN: 1838-7640
Titre abrégé: Theranostics
Pays: Australia
ID NLM: 101552395
Informations de publication
Date de publication:
2020
2020
Historique:
received:
27
07
2020
accepted:
04
10
2020
entrez:
18
11
2020
pubmed:
19
11
2020
medline:
2
6
2021
Statut:
epublish
Résumé
Calcium oxalate (CaOx) crystal can trigger kidney injury, which contributes to the pathogenesis of nephrocalcinosis. The phenotypes of infiltrating macrophage may impact CaOx-mediated kidney inflammatory injury as well as crystal deposition. How aryl hydrocarbon receptor (AhR) regulates inflammation and macrophage polarization is well understood; however, how it modulates CaOx nephrocalcinosis remains unclear.
Identifiants
pubmed: 33204326
doi: 10.7150/thno.51144
pii: thnov10p12011
pmc: PMC7667681
doi:
Substances chimiques
3' Untranslated Regions
0
6-formylindolo(3,2-b)carbazole
0
AHR protein, human
0
Ahr protein, mouse
0
Basic Helix-Loop-Helix Transcription Factors
0
Carbazoles
0
Glyoxylates
0
Hif1a protein, mouse
0
Hypoxia-Inducible Factor 1, alpha Subunit
0
Interferon Regulatory Factor-1
0
Irf1 protein, mouse
0
MicroRNAs
0
Mirn142 microRNA, mouse
0
Receptors, Aryl Hydrocarbon
0
Calcium Oxalate
2612HC57YE
glyoxylic acid
JQ39C92HH6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
12011-12025Informations de copyright
© The author(s).
Déclaration de conflit d'intérêts
Competing Interests: The authors have declared that no competing interest exists.
Références
J Neuroinflammation. 2017 Mar 16;14(1):55
pubmed: 28302134
Rev Urol. 2010 Spring;12(2-3):e86-96
pubmed: 20811557
Biomed Pharmacother. 2020 Jan;121:109606
pubmed: 31743875
J Transl Med. 2018 Sep 17;16(1):257
pubmed: 30223848
Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1122-6
pubmed: 22232670
Kidney Int. 2018 Mar;93(3):656-669
pubmed: 29241624
RNA. 2007 Mar;13(3):385-95
pubmed: 17237357
J Mol Biol. 1999 Jun 11;289(3):459-71
pubmed: 10356322
Nat Commun. 2016 Jan 28;7:10274
pubmed: 26817517
Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):15989-94
pubmed: 16236719
J Clin Invest. 2007 May;117(5):1155-66
pubmed: 17476345
Thorax. 2019 Sep;74(9):865-874
pubmed: 31331947
Theranostics. 2020 Jul 25;10(21):9561-9578
pubmed: 32863945
Lab Invest. 2019 May;99(5):671-683
pubmed: 30700847
Chem Biol Interact. 2016 Feb 25;246:30-5
pubmed: 26748311
Sci Rep. 2016 Oct 12;6:35167
pubmed: 27731368
Mol Immunol. 2007 Jan;44(4):338-46
pubmed: 16597464
Cell Commun Signal. 2020 May 4;18(1):70
pubmed: 32366266
Redox Biol. 2015 Aug;5:398-408
pubmed: 26163808
BJU Int. 2017 Jul;120(1):109-116
pubmed: 28236332
Nature. 2013 Apr 11;496(7444):238-42
pubmed: 23535595
J Bone Miner Res. 2010 Dec;25(12):2701-11
pubmed: 20577968
J Histochem Cytochem. 1964 May;12:333-6
pubmed: 14193854
EBioMedicine. 2019 Dec;50:366-378
pubmed: 31735555
Nat Commun. 2015 Oct 05;6:8523
pubmed: 26436920
Curr Opin Clin Nutr Metab Care. 2003 Mar;6(2):223-8
pubmed: 12589193
Chin Med J (Engl). 2002 Dec;115(12):1833-7
pubmed: 12622934
Annu Rev Immunol. 2014;32:403-32
pubmed: 24655296
Nat Rev Immunol. 2003 Jan;3(1):23-35
pubmed: 12511873
J Am Soc Nephrol. 2014 Aug;25(8):1680-97
pubmed: 24578130
J Urol. 2015 Dec;194(6):1787-96
pubmed: 26192255
FASEB J. 2019 Apr;33(4):5208-5219
pubmed: 30624969
Immunity. 2014 Jun 19;40(6):989-1001
pubmed: 24909886
J Am Soc Nephrol. 1999 Nov;10(11):2323-31
pubmed: 10541291
Trends Immunol. 2004 Dec;25(12):677-86
pubmed: 15530839
Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14222-7
pubmed: 21825138
Am J Physiol Renal Physiol. 2008 Oct;295(4):F1023-9
pubmed: 18667485
Nat Commun. 2014 Aug 20;5:4738
pubmed: 25141024
Br J Pharmacol. 1996 Aug;118(8):2178-84
pubmed: 8864559
Biochem Pharmacol. 2000 Apr 15;59(8):997-1005
pubmed: 10692565
J Biol Chem. 2005 May 27;280(21):20340-8
pubmed: 15790560
Hypertension. 2015 Jul;66(1):75-84
pubmed: 25987665
BMC Nephrol. 2020 Jul 13;21(1):270
pubmed: 32660446
Genes Dev. 2010 Mar 1;24(5):491-501
pubmed: 20194441
Gastroenterology. 2011 Jul;141(1):237-48, 248.e1
pubmed: 21600206
Adv Chronic Kidney Dis. 2017 Mar;24(2):57-63
pubmed: 28284380
Urol Res. 2007 Apr;35(2):89-99
pubmed: 17393196
Theranostics. 2020 Jun 5;10(16):7319-7334
pubmed: 32641994
J Clin Invest. 2013 Jan;123(1):236-46
pubmed: 23221343
Annu Rev Immunol. 2016 May 20;34:173-202
pubmed: 26772211
Pediatr Nephrol. 2010 May;25(5):831-41
pubmed: 19198886
Clin Nucl Med. 2017 Feb;42(2):112-113
pubmed: 27879491
Nat Rev Nephrol. 2019 Apr;15(4):220-239
pubmed: 30651611
J Exp Med. 2009 Aug 31;206(9):2027-35
pubmed: 19703987
Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):16001-6
pubmed: 16243976
J Immunol Res. 2018 Jan 14;2018:8917804
pubmed: 29507865
Biochem Pharmacol. 2018 Sep;155:494-509
pubmed: 30071202
J Nucl Med. 2001 Oct;42(10):1551-5
pubmed: 11585872
Am J Physiol Renal Physiol. 2019 Jul 1;317(1):F137-F151
pubmed: 31091119
J Biol Chem. 1997 May 2;272(18):12236-43
pubmed: 9115299
Biochemistry (Mosc). 2012 Mar;77(3):246-60
pubmed: 22803942
Front Immunol. 2019 Apr 17;10:799
pubmed: 31057539
Sci Rep. 2017 Aug 18;7(1):8801
pubmed: 28821730
J Urol. 2014 Jun;191(6):1906-12
pubmed: 24518782
Life Sci. 2016 Jun 15;155:76-84
pubmed: 27153778
Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2849-54
pubmed: 17293456
J Clin Invest. 2012 Mar;122(3):787-95
pubmed: 22378047
Nutr Rev. 2013 Jun;71(6):353-69
pubmed: 23731446
J Bone Miner Res. 2009 May;24(5):908-24
pubmed: 19113933
Am J Kidney Dis. 1999 Apr;33(4):761-71
pubmed: 10196021
Kidney Int. 2002 Jan;61(1):105-12
pubmed: 11786090
Cell. 2004 Jan 23;116(2):281-97
pubmed: 14744438
Nat Rev Nephrol. 2019 Aug;15(8):501-520
pubmed: 31164720