The deubiquitylase Ubp15 couples transcription to mRNA export.

Endopeptidases Gene Deletion Gene Expression Regulation, Fungal Mass Spectrometry Nuclear Pore / genetics Nuclear Proteins / genetics Nucleocytoplasmic Transport Proteins / genetics RNA Polymerase II / genetics RNA, Messenger RNA-Binding Proteins / genetics Saccharomyces cerevisiae / enzymology Saccharomyces cerevisiae Proteins / genetics Transcription, Genetic
Mex67 Rsp5 S. cerevisiae Ubp15 chromosomes deubiquitylase gene expression genetics genomics nuclear export transcription

Journal

eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614

Informations de publication

Date de publication:
23 11 2020
Historique:
received: 20 07 2020
accepted: 04 11 2020
entrez: 23 11 2020
pubmed: 24 11 2020
medline: 23 3 2021
Statut: epublish

Résumé

Nuclear export of messenger RNAs (mRNAs) is intimately coupled to their synthesis. pre-mRNAs assemble into dynamic ribonucleoparticles as they are being transcribed, processed, and exported. The role of ubiquitylation in this process is increasingly recognized but, while a few E3 ligases have been shown to regulate nuclear export, evidence for deubiquitylases is currently lacking. Here we identified deubiquitylase Ubp15 as a regulator of nuclear export in

Identifiants

DOI: 10.7554/eLife.61264 PMID: 33226341 PMC: PMC7682988
pubmed: 33226341
doi: 10.7554/eLife.61264
pii: 61264
pmc: PMC7682988
doi:
pii:

Substances chimiques

MEX67 protein, S cerevisiae 0
Nuclear Proteins 0
Nucleocytoplasmic Transport Proteins 0
RNA, Messenger 0
RNA-Binding Proteins 0
Saccharomyces cerevisiae Proteins 0
RNA Polymerase II EC 2.7.7.-
Endopeptidases EC 3.4.-
Ubp15 protein, S cerevisiae EC 3.4.99.-

Banques de données

GEO
['GSE154671']

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Natural Sciences and Engineering Research Council of Canada
ID : 435833-2013
Pays : International
Organisme : CIHR
ID : MOP-162334
Pays : Canada
Organisme : CIHR
ID : FDN-143314
Pays : Canada

Informations de copyright

© 2020, Eyboulet et al.

Déclaration de conflit d'intérêts

FE, CJ, JC, FR No competing interests declared

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Auteurs

Fanny Eyboulet (F)

Institut de recherches cliniques de Montréal, Montréal, Canada.
St-Patrick Research Group in Basic Oncology, Laval University Cancer Research Center, Axe Oncologie du Centre de Recherche du CHU de Québec-Université Laval, Québec City, Canada.

Célia Jeronimo (C)

Institut de recherches cliniques de Montréal, Montréal, Canada.

Jacques Côté (J)

St-Patrick Research Group in Basic Oncology, Laval University Cancer Research Center, Axe Oncologie du Centre de Recherche du CHU de Québec-Université Laval, Québec City, Canada.
ORCID: 0000-0001-6751-555X

François Robert (F)

Institut de recherches cliniques de Montréal, Montréal, Canada.
Département de Médecine, Faculté de Médecine, Université de Montréal, Montréal, Canada.
ORCID: 0000-0003-1054-5920

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Endopeptidases › The deubiquitylase Ubp15 couples transcription...
questionsmedicales.fr › Phénomènes génétiques › Mutagenèse › Délétion de séquence › Délétion de gène › The deubiquitylase Ubp15 couples transcription...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes fongiques › The deubiquitylase Ubp15 couples transcription...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Spectrométrie de masse › The deubiquitylase Ubp15 couples transcription...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Structures nucléaires › Pore nucléaire › The deubiquitylase Ubp15 couples transcription...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines nucléaires › The deubiquitylase Ubp15 couples transcription...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Transporteurs nucléocytoplasmiques › The deubiquitylase Ubp15 couples transcription...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Nucleotidyltransferases › RNA nucleotidyltransferases › DNA-directed RNA polymerases › RNA polymerase II › The deubiquitylase Ubp15 couples transcription...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN messager › The deubiquitylase Ubp15 couples transcription...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines de liaison à l'ARN › The deubiquitylase Ubp15 couples transcription...
questionsmedicales.fr › Eucaryotes › Champignons › Levures › Saccharomyces › Saccharomyces cerevisiae › The deubiquitylase Ubp15 couples transcription...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines fongiques › Protéines de Saccharomyces cerevisiae › The deubiquitylase Ubp15 couples transcription...
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › Transcription génétique › The deubiquitylase Ubp15 couples transcription...