Single-cell profiling reveals the trajectories of natural killer cell differentiation in bone marrow and a stress signature induced by acute myeloid leukemia.
AML
NK cells
scRNASeq
Journal
Cellular & molecular immunology
ISSN: 2042-0226
Titre abrégé: Cell Mol Immunol
Pays: China
ID NLM: 101242872
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
received:
29
08
2020
accepted:
13
10
2020
revised:
12
10
2020
pubmed:
27
11
2020
medline:
28
1
2022
entrez:
26
11
2020
Statut:
ppublish
Résumé
Natural killer (NK) cells are innate cytotoxic lymphoid cells (ILCs) involved in the killing of infected and tumor cells. Among human and mouse NK cells from the spleen and blood, we previously identified by single-cell RNA sequencing (scRNAseq) two similar major subsets, NK1 and NK2. Using the same technology, we report here the identification, by single-cell RNA sequencing (scRNAseq), of three NK cell subpopulations in human bone marrow. Pseudotime analysis identified a subset of resident CD56
Identifiants
pubmed: 33239726
doi: 10.1038/s41423-020-00574-8
pii: 10.1038/s41423-020-00574-8
pmc: PMC8093261
doi:
Substances chimiques
Antigens, CD
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1290-1304Commentaires et corrections
Type : CommentIn
Type : CommentIn
Type : ErratumIn
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