Charting a DNA Repair Roadmap for Immunoglobulin Class Switch Recombination.
DNA double-strand breaks
alternative end joining
antibody-mediated responses
class switch recombination
immunoglobulin heavy chain locus
nonhomologous end joining
Journal
Trends in biochemical sciences
ISSN: 0968-0004
Titre abrégé: Trends Biochem Sci
Pays: England
ID NLM: 7610674
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
15
07
2020
revised:
08
10
2020
accepted:
23
10
2020
pubmed:
1
12
2020
medline:
18
9
2021
entrez:
30
11
2020
Statut:
ppublish
Résumé
Immunoglobulin (Ig) class switch recombination (CSR) is the process occurring in mature B cells that diversifies the effector component of antibody responses. CSR is initiated by the activity of the B cell-specific enzyme activation-induced cytidine deaminase (AID), which leads to the formation of programmed DNA double-strand breaks (DSBs) at the Ig heavy chain (Igh) locus. Mature B cells use a multilayered and complex regulatory framework to ensure that AID-induced DNA breaks are channeled into productive repair reactions leading to CSR, and to avoid aberrant repair events causing lymphomagenic chromosomal translocations. Here, we review the DNA repair pathways acting on AID-induced DSBs and their functional interplay, with a particular focus on the latest developments in their molecular composition and mechanistic regulation.
Identifiants
pubmed: 33250286
pii: S0968-0004(20)30267-X
doi: 10.1016/j.tibs.2020.10.005
pii:
doi:
Substances chimiques
Immunoglobulin Heavy Chains
0
Cytidine Deaminase
EC 3.5.4.5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
184-199Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.