A Performance Comparison of Commonly Used Assays to Detect RET Fusions.


Journal

Clinical cancer research : an official journal of the American Association for Cancer Research
ISSN: 1557-3265
Titre abrégé: Clin Cancer Res
Pays: United States
ID NLM: 9502500

Informations de publication

Date de publication:
01 03 2021
Historique:
received: 17 08 2020
revised: 23 10 2020
accepted: 30 11 2020
pubmed: 5 12 2020
medline: 11 2 2022
entrez: 4 12 2020
Statut: ppublish

Résumé

Selpercatinib and pralsetinib induce deep and durable responses in patients with advanced Tumors underwent DNA-based next-generation sequencing (NGS) with reflex to RNA-based NGS if no mitogenic driver or if a A total of 171 of 41,869 patients with DNA NGS harbored Although DNA sequencing has high sensitivity and specificity, RNA sequencing of

Identifiants

pubmed: 33272981
pii: 1078-0432.CCR-20-3208
doi: 10.1158/1078-0432.CCR-20-3208
pmc: PMC8285056
mid: NIHMS1718749
doi:

Substances chimiques

Biomarkers, Tumor 0
Oncogene Proteins, Fusion 0
Proto-Oncogene Proteins c-ret EC 2.7.10.1
RET protein, human EC 2.7.10.1

Types de publication

Comparative Study Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1316-1328

Subventions

Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States

Informations de copyright

©2020 American Association for Cancer Research.

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Auteurs

Soo-Ryum Yang (SR)

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York. yangs2@mskcc.org.

Umut Aypar (U)

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.

Ezra Y Rosen (EY)

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

Douglas A Mata (DA)

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.

Ryma Benayed (R)

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.

Kerry Mullaney (K)

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.

Gowtham Jayakumaran (G)

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.

Yanming Zhang (Y)

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.

Denise Frosina (D)

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.

Alexander Drilon (A)

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

Marc Ladanyi (M)

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.

Achim A Jungbluth (AA)

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.

Natasha Rekhtman (N)

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.

Jaclyn F Hechtman (JF)

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.

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Classifications MeSH