Functional Characterization of the γ-Aminobutyric Acid Transporter from Mycobacterium smegmatis MC

Bacterial Proteins / genetics Biological Transport / physiology Escherichia coli / genetics Escherichia coli Proteins GABA Plasma Membrane Transport Proteins / genetics Gene Expression Regulation, Bacterial Metabolomics Molecular Docking Simulation Mycobacterium smegmatis / metabolism Organic Anion Transporters / genetics Phylogeny Sodium / metabolism gamma-Aminobutyric Acid / chemistry
GABA membrane biology mycobacteria transporter

Journal

Journal of bacteriology
ISSN: 1098-5530
Titre abrégé: J Bacteriol
Pays: United States
ID NLM: 2985120R

Informations de publication

Date de publication:
25 01 2021
Historique:
received: 18 11 2020
accepted: 18 11 2020
pubmed: 9 12 2020
medline: 15 7 2021
entrez: 8 12 2020
Statut: epublish

Résumé

Characterizing the mycobacterial transporters involved in the uptake and/or catabolism of host-derived nutrients required by mycobacteria may identify novel drug targets against tuberculosis. Here, we identify and characterize a member of the amino acid-polyamine-organocation superfamily, a potential γ-aminobutyric acid (GABA) transport protein, GabP, from

Identifiants

DOI: 10.1128/JB.00642-20 PMID: 33288625 PMC: PMC7847548
pubmed: 33288625
pii: JB.00642-20
doi: 10.1128/JB.00642-20
pmc: PMC7847548
pii:
doi:

Substances chimiques

Bacterial Proteins 0
Escherichia coli Proteins 0
GABA Plasma Membrane Transport Proteins 0
Organic Anion Transporters 0
gabP protein, E coli 0
gamma-Aminobutyric Acid 56-12-2
Sodium 9NEZ333N27

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : M021610
Pays : United Kingdom
Organisme : Wellcome Trust
ID : FC0010060
Pays : United Kingdom

Informations de copyright

Copyright © 2021 Pavić et al.

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Auteurs

Ana Pavić (A)

Astbury Centre for Structural Molecular Biology, School of Biomedical Sciences, University of Leeds, Leeds, United Kingdom.
Biomedicine Research Group, Faculty of Health and Social Sciences, Leeds Beckett University, Leeds, United Kingdom.

Yurui Ji (Y)

Astbury Centre for Structural Molecular Biology, School of Biomedical Sciences, University of Leeds, Leeds, United Kingdom.
College of Environmental Sciences & Engineering, Nankai University, Tianjin, China.

Agnese Serafini (A)

Mycobacterial Metabolism and Antibiotic Research Laboratory, The Francis Crick Institute, London, United Kingdom.

Acely Garza-Garcia (A)

Mycobacterial Metabolism and Antibiotic Research Laboratory, The Francis Crick Institute, London, United Kingdom.

Martin J McPhillie (MJ)

School of Chemistry, Faculty of Engineering & Physical Sciences, University of Leeds, Leeds, United Kingdom.

Alexandra O M Holmes (AOM)

Astbury Centre for Structural Molecular Biology, School of Biomedical Sciences, University of Leeds, Leeds, United Kingdom.

Luiz Pedro Sório de Carvalho (LPS)

Mycobacterial Metabolism and Antibiotic Research Laboratory, The Francis Crick Institute, London, United Kingdom.

Yingying Wang (Y)

College of Environmental Sciences & Engineering, Nankai University, Tianjin, China.

Mark Bartlam (M)

College of Life Sciences, Nankai University, Tianjin, China bartlam@nankai.edu.cn A.Goldman@leeds.ac.uk v.l.postis@leedsbeckett.ac.uk.
ORCID: 0000-0001-5173-5080

Adrian Goldman (A)

Astbury Centre for Structural Molecular Biology, School of Biomedical Sciences, University of Leeds, Leeds, United Kingdom bartlam@nankai.edu.cn A.Goldman@leeds.ac.uk v.l.postis@leedsbeckett.ac.uk.
College of Life Sciences, Nankai University, Tianjin, China.
Molecular and Integrative Biosciences, University of Helsinki, Helsinki, Finland.
ORCID: 0000-0001-8032-9700

Vincent L G Postis (VLG)

Astbury Centre for Structural Molecular Biology, School of Biomedical Sciences, University of Leeds, Leeds, United Kingdom bartlam@nankai.edu.cn A.Goldman@leeds.ac.uk v.l.postis@leedsbeckett.ac.uk.
Biomedicine Research Group, Faculty of Health and Social Sciences, Leeds Beckett University, Leeds, United Kingdom.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › Functional Characterization of the...
questionsmedicales.fr › Métabolisme › Transport biologique › Functional Characterization of the...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Escherichia › Escherichia coli › Functional Characterization of the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › Protéines Escherichia coli › Functional Characterization of the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Transporteurs de neurotransmetteurs › Transporteurs plasmiques de neurotransmetteurs › Transporteurs de GABA › Functional Characterization of the...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes bactériens › Functional Characterization of the...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Métabolomique › Functional Characterization of the...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Functional Characterization of the...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets asporogènes à Gram positif › Bâtonnets asporogènes réguliers à Gram positif › Mycobacteriaceae › Mycobacterium › Mycobactéries non tuberculeuses › Mycobacterium smegmatis › Functional Characterization of the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Pompes ioniques › Transporteurs d'anions › Transporteurs d'anions organiques › Functional Characterization of the...
questionsmedicales.fr › Sciences de l'information › Phylogenèse › Functional Characterization of the...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux légers › Sodium › Functional Characterization of the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Amino-butyrates › Acide gamma-amino-butyrique › Functional Characterization of the...