AGE-RAGE Axis Stimulates Oxidized LDL Uptake into Macrophages through Cyclin-Dependent Kinase 5-CD36 Pathway via Oxidative Stress Generation.
Animals
Aptamers, Nucleotide
CD36 Antigens
/ genetics
Cyclin-Dependent Kinase 5
/ genetics
Glycation End Products, Advanced
/ metabolism
Humans
Lipoproteins, LDL
/ metabolism
Macrophages
/ metabolism
Models, Biological
Oxidative Stress
Receptor for Advanced Glycation End Products
/ metabolism
U937 Cells
AGEs
CD36
Cdk5
RAGE-aptamer
macrophages
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
04 Dec 2020
04 Dec 2020
Historique:
received:
20
11
2020
revised:
28
11
2020
accepted:
01
12
2020
entrez:
9
12
2020
pubmed:
10
12
2020
medline:
9
3
2021
Statut:
epublish
Résumé
Advanced glycation end products (AGEs) are localized in macrophage-derived foam cells within atherosclerotic lesions, which could be associated with the increased risk of atherosclerotic cardiovascular disease under diabetic conditions. Although foam cell formation of macrophages has been shown to be enhanced by AGEs, the underlying molecular mechanism remains unclear. Since cyclin-dependent kinase 5 (Cdk5) is reported to modulate inflammatory responses in macrophages, we investigated whether Cdk5 could be involved in AGE-induced
Identifiants
pubmed: 33291667
pii: ijms21239263
doi: 10.3390/ijms21239263
pmc: PMC7730944
pii:
doi:
Substances chimiques
Aptamers, Nucleotide
0
CD36 Antigens
0
Glycation End Products, Advanced
0
Lipoproteins, LDL
0
Receptor for Advanced Glycation End Products
0
oxidized low density lipoprotein
0
Cyclin-Dependent Kinase 5
EC 2.7.11.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : JSPS KAKENHI
ID : 20K07075
Organisme : JSPS KAKENHI
ID : 20K06475
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