Selective Chemical Functionalization at N6-Methyladenosine Residues in DNA Enabled by Visible-Light-Mediated Photoredox Catalysis.


Journal

Journal of the American Chemical Society
ISSN: 1520-5126
Titre abrégé: J Am Chem Soc
Pays: United States
ID NLM: 7503056

Informations de publication

Date de publication:
23 12 2020
Historique:
pubmed: 12 12 2020
medline: 20 4 2021
entrez: 11 12 2020
Statut: ppublish

Résumé

Selective chemistry that modifies the structure of DNA and RNA is essential to understanding the role of epigenetic modifications. We report a visible-light-activated photocatalytic process that introduces a covalent modification at a C(sp

Identifiants

pubmed: 33305571
doi: 10.1021/jacs.0c10616
pmc: PMC7760100
doi:

Substances chimiques

Amines 0
Hydrogen 7YNJ3PO35Z
DNA 9007-49-2
Adenosine K72T3FS567
Nitrogen N762921K75

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

21484-21492

Subventions

Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 209441/Z/17/Z
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C9681/A18618
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C14303/A17197
Pays : United Kingdom

Références

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Auteurs

Manuel Nappi (M)

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom.

Alexandre Hofer (A)

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom.

Shankar Balasubramanian (S)

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom.
Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, United Kingdom.
School of Clinical Medicine, University of Cambridge, Cambridge CB2 0SP, United Kingdom.

Matthew J Gaunt (MJ)

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom.

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Classifications MeSH