Contribution of PDGFRα lineage cells in adult mouse hematopoiesis.
Bone marrow
Hematopoietic cell
Mesoderm
PDGFRα
Single-cell RNA-sequencing
Journal
Biochemical and biophysical research communications
ISSN: 1090-2104
Titre abrégé: Biochem Biophys Res Commun
Pays: United States
ID NLM: 0372516
Informations de publication
Date de publication:
01 01 2021
01 01 2021
Historique:
received:
26
11
2020
accepted:
27
11
2020
pubmed:
15
12
2020
medline:
10
4
2021
entrez:
14
12
2020
Statut:
ppublish
Résumé
Platelet-derived growth factor receptor alpha (PDGFRα) is a dominant marker of mesodermal mesenchymal cells in mice. Previous studies demonstrated that PDGFRα-positive (PDGFRα+) mesodermal cells develop not only into mesenchymal cells but also into a subset of total hematopoietic cells (HCs) in the limited period during mouse embryogenesis. However, the precise characteristics of the PDGFRα lineage positive (PDGFRα Lin+) HCs in adult mouse hematopoiesis are largely unknown. In this study, we systematically evaluated the characteristics of PDGFRα Lin+ HCs in the bone marrow and peripheral blood using PDGFRα-CRE; ROSA
Identifiants
pubmed: 33309273
pii: S0006-291X(20)32158-6
doi: 10.1016/j.bbrc.2020.11.114
pii:
doi:
Substances chimiques
Receptor, Platelet-Derived Growth Factor alpha
EC 2.7.10.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
186-192Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Conflicts of interest K.T. is a scientific founder of and received research funding from StemRIM. K.T. and T.S. are stockholders of StemRIM. T.K., Y.O., S.Y., M.N., E.T., R.Y., and E.W. are employees of StemRIM. A.M declares no conflict of interest in this study.