Alcohol dependence activates ventral tegmental area projections to central amygdala in male mice and rats.
alcohol
central amygdala
dependence
electrophysiology
mouse
optogenetics
rat
ventral tegmental area
Journal
Addiction biology
ISSN: 1369-1600
Titre abrégé: Addict Biol
Pays: United States
ID NLM: 9604935
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
revised:
30
09
2020
received:
21
04
2020
accepted:
05
11
2020
pubmed:
18
12
2020
medline:
15
12
2021
entrez:
17
12
2020
Statut:
ppublish
Résumé
The neural adaptations that occur during the transition to alcohol dependence are not entirely understood but may include a gradual recruitment of brain stress circuitry by mesolimbic reward circuitry that is activated during early stages of alcohol use. Here, we focused on dopaminergic and nondopaminergic projections from the ventral tegmental area (VTA), important for mediating acute alcohol reinforcement, to the central nucleus of the amygdala (CeA), important for alcohol dependence-related negative affect and escalated alcohol drinking. The VTA projects directly to the CeA, but the functional relevance of this circuit is not fully established. Therefore, we combined retrograde and anterograde tracing, anatomical, and electrophysiological experiments in mice and rats to demonstrate that the CeA receives input from both dopaminergic and nondopaminergic projection neurons primarily from the lateral VTA. We then used slice electrophysiology and fos immunohistochemistry to test the effects of alcohol dependence on activity and activation profiles of CeA-projecting neurons in the VTA. Our data indicate that alcohol dependence activates midbrain projections to the central amygdala, suggesting that VTA projections may trigger plasticity in the CeA during the transition to alcohol dependence and that this circuit may be involved in mediating behavioral dysregulation associated with alcohol dependence.
Identifiants
pubmed: 33331103
doi: 10.1111/adb.12990
pmc: PMC8206248
mid: NIHMS1685916
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12990Subventions
Organisme : NIAAA NIH HHS
ID : F32 AA025831
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA023305
Pays : United States
Organisme : NIAAA NIH HHS
ID : K99 AA022651
Pays : United States
Organisme : BLRD VA
ID : I01 BX003451
Pays : United States
Organisme : NIAAA NIH HHS
ID : T32 AA007577
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA026531
Pays : United States
Organisme : NIAAA NIH HHS
ID : R00 AA022651
Pays : United States
Informations de copyright
© 2020 Society for the Study of Addiction.
Références
Brain Res. 1990 Jan 29;508(1):65-9
pubmed: 2337793
Neuron. 2011 Jun 9;70(5):855-62
pubmed: 21658580
J Neurosci. 2018 Sep 5;38(36):7761-7773
pubmed: 30054393
Brain Res. 1995 Sep 18;692(1-2):47-56
pubmed: 8548319
Neuron. 2019 Aug 7;103(3):473-488.e6
pubmed: 31202540
Neurosci Lett. 2006 May 29;400(1-2):140-5
pubmed: 16563623
eNeuro. 2018 Feb 6;5(1):
pubmed: 29445764
Neuroscience. 2017 Dec 26;367:159-168
pubmed: 29111360
Mol Psychiatry. 2011 Oct;16(10):1024-38
pubmed: 21483433
J Neurosci. 2019 Feb 6;39(6):1030-1043
pubmed: 30530860
Eur J Neurosci. 2015 Mar;41(6):760-72
pubmed: 25572002
Neuropharmacology. 2016 Nov;110(Pt A):386-395
pubmed: 27475082
Int Rev Neurobiol. 2010;91:235-88
pubmed: 20813245
Neuron. 2019 Jun 5;102(5):1037-1052.e7
pubmed: 31029403
Alcohol Clin Exp Res. 2008 Oct;32(10):1714-20
pubmed: 18627359
J Neurosci. 2012 Mar 7;32(10):3405-13
pubmed: 22399763
J Comp Neurol. 2019 Apr 1;527(5):916-941
pubmed: 30393861
Curr Protoc Neurosci. 2008 Jul;Chapter 9:Unit 9.29
pubmed: 18634001
J Neurosci. 2020 Jan 15;40(3):632-647
pubmed: 31744862
Alcohol Clin Exp Res. 2015 Sep;39(9):1609-18
pubmed: 26247973
J Neurosci. 2004 Nov 10;24(45):10159-66
pubmed: 15537886
Neuroscience. 2008 Apr 9;152(4):1024-31
pubmed: 18355970
Biol Psychiatry. 2015 May 15;77(10):859-69
pubmed: 25433901
Neuroscience. 2015 Apr 2;290:649-58
pubmed: 25660505
J Neurosci. 2015 Dec 9;35(49):16259-71
pubmed: 26658874
Brain Res. 2009 Oct 13;1293:61-75
pubmed: 19332030
Bio Protoc. 2019 May 5;9(9):
pubmed: 31428664
Alcohol Clin Exp Res. 1993 Feb;17(1):94-8
pubmed: 8452212
Alcohol Clin Exp Res. 2017 Mar;41(3):551-561
pubmed: 28097729
J Physiol. 2006 Dec 15;577(Pt 3):907-24
pubmed: 16959856
Neuropharmacology. 2014 Jan;76 Pt B:351-9
pubmed: 23578393
Br J Pharmacol. 2020 Apr;177(7):1525-1537
pubmed: 31713848
Neuropsychopharmacology. 1998 Jul;19(1):48-59
pubmed: 9608576
Alcohol. 2014 May;48(3):277-86
pubmed: 24290310
Nat Rev Neurosci. 2017 Feb;18(2):73-85
pubmed: 28053327
Nature. 2016 Jun 01;534(7606):206-12
pubmed: 27279213
Nature. 2015 Jan 15;517(7534):284-92
pubmed: 25592533
Alcohol. 2013 Aug;47(5):367-80
pubmed: 23714385
J Neurosci. 2010 Apr 21;30(16):5713-23
pubmed: 20410123
J Neurosci. 2013 Mar 6;33(10):4527-35
pubmed: 23467368
Front Neural Circuits. 2010 Aug 26;4:100
pubmed: 21960959
Alcohol. 1994 Nov-Dec;11(6):557-64
pubmed: 7865158
Biol Psychiatry. 2016 Mar 15;79(6):430-42
pubmed: 25579851
Behav Brain Res. 2014 Oct 1;272:238-47
pubmed: 25026094
Am J Prev Med. 2015 Nov;49(5):e73-e79
pubmed: 26477807
J Neurosci. 2004 Feb 18;24(7):1594-603
pubmed: 14973247