Cerebellar nuclei evolved by repeatedly duplicating a conserved cell-type set.
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
18 12 2020
18 12 2020
Historique:
received:
24
06
2020
accepted:
26
10
2020
entrez:
18
12
2020
pubmed:
19
12
2020
medline:
9
2
2021
Statut:
ppublish
Résumé
How have complex brains evolved from simple circuits? Here we investigated brain region evolution at cell-type resolution in the cerebellar nuclei, the output structures of the cerebellum. Using single-nucleus RNA sequencing in mice, chickens, and humans, as well as STARmap spatial transcriptomic analysis and whole-central nervous system projection tracing, we identified a conserved cell-type set containing two region-specific excitatory neuron classes and three region-invariant inhibitory neuron classes. This set constitutes an archetypal cerebellar nucleus that was repeatedly duplicated to form new regions. The excitatory cell class that preferentially funnels information to lateral frontal cortices in mice becomes predominant in the massively expanded human lateral nucleus. Our data suggest a model of brain region evolution by duplication and divergence of entire cell-type sets.
Identifiants
pubmed: 33335034
pii: 370/6523/eabd5059
doi: 10.1126/science.abd5059
pmc: PMC8510508
mid: NIHMS1700612
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NINDS NIH HHS
ID : R01 NS050835
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS091144
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS104698
Pays : United States
Organisme : NHGRI NIH HHS
ID : RM1 HG007735
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
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