Cholinergic Chemotransmission and Anesthetic Drug Effects at the Carotid Bodies.
Acetylcholine
/ metabolism
Anesthesia, General
/ adverse effects
Anesthetics, General
/ pharmacology
Carotid Body
/ drug effects
Cholinergic Agents
/ pharmacology
Cholinergic Neurons
/ drug effects
Delayed Emergence from Anesthesia
/ prevention & control
Humans
Hypnotics and Sedatives
/ pharmacology
Muscle Relaxants, Central
/ pharmacology
Propofol
/ pharmacology
Receptors, Nicotinic
/ drug effects
Respiration
/ drug effects
Respiration, Artificial
anesthesia
cholinergic transmission
muscle relaxants
peripheral chemosensitivity
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
17 Dec 2020
17 Dec 2020
Historique:
received:
13
10
2020
revised:
08
12
2020
accepted:
15
12
2020
entrez:
22
12
2020
pubmed:
23
12
2020
medline:
8
9
2021
Statut:
epublish
Résumé
General anesthesia is obtained by administration of potent hypnotics, analgesics and muscle relaxants. Apart from their intended effects (loss of consciousness, pain relief and muscle relaxation), these agents profoundly affect the control of breathing, in part by an effect within the peripheral chemoreflex loop that originates at the carotid bodies. This review assesses the role of cholinergic chemotransmission in the peripheral chemoreflex loop and the mechanisms through which muscle relaxants and hypnotics interfere with peripheral chemosensitivity. Additionally, consequences for clinical practice are discussed.
Identifiants
pubmed: 33348537
pii: molecules25245974
doi: 10.3390/molecules25245974
pmc: PMC7765955
pii:
doi:
Substances chimiques
Anesthetics, General
0
Cholinergic Agents
0
Hypnotics and Sedatives
0
Muscle Relaxants, Central
0
Receptors, Nicotinic
0
Acetylcholine
N9YNS0M02X
Propofol
YI7VU623SF
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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