Distinct developmental pathways from blood monocytes generate human lung macrophage diversity.
Antigens, CD34
/ metabolism
Biodiversity
Cell Differentiation
Cell Movement
Cells, Cultured
Fetal Blood
/ cytology
Hematopoietic Stem Cells
/ immunology
Humans
Lipopolysaccharide Receptors
/ metabolism
Lung
/ blood supply
Macrophages, Alveolar
/ immunology
Monocytes
/ immunology
Receptors, IgG
/ metabolism
Sequence Analysis, RNA
Single-Cell Analysis
Stem Cell Niche
blood monocytes
fate mapping
human macrophages
humanized mice
intravascular macrophages
lung
ontogeny
origin
single-cell RNA sequencing
Journal
Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918
Informations de publication
Date de publication:
09 02 2021
09 02 2021
Historique:
received:
18
05
2020
revised:
15
10
2020
accepted:
08
12
2020
pubmed:
1
1
2021
medline:
8
9
2021
entrez:
31
12
2020
Statut:
ppublish
Résumé
The study of human macrophages and their ontogeny is an important unresolved issue. Here, we use a humanized mouse model expressing human cytokines to dissect the development of lung macrophages from human hematopoiesis in vivo. Human CD34
Identifiants
pubmed: 33382972
pii: S1074-7613(20)30531-8
doi: 10.1016/j.immuni.2020.12.003
pii:
doi:
Substances chimiques
Antigens, CD34
0
Lipopolysaccharide Receptors
0
Receptors, IgG
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
259-275.e7Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.