Enzymology and biosynthesis of the orsellinic acid derived medicinal meroterpenoids.

Biological Products Biosynthetic Pathways / genetics Fungi Genomics Resorcinols

Journal

Current opinion in biotechnology
ISSN: 1879-0429
Titre abrégé: Curr Opin Biotechnol
Pays: England
ID NLM: 9100492

Informations de publication

Date de publication:
06 2021
Historique:
received: 29 05 2020
revised: 02 11 2020
accepted: 30 11 2020
pubmed: 1 1 2021
medline: 3 7 2021
entrez: 31 12 2020
Statut: ppublish

Résumé

The advent of synthetic biology has yielded fruitful studies on orsellinic acid-derived meroterpenoids, which reportedly possess important biological activities. Genomics and transcriptomics have significantly accelerated the discovery of the biosynthetic genes for orsellinic acid-derived fungal and plant meroterpenoids. Subsequently, a well-developed heterologous host provides a convenient platform to generate a supply of useful natural products. Furthermore, in vitro reconstitution and genome editing tools have been increasingly employed as efficient means to fully understand the enzyme reaction mechanisms. With the knowledge of the biosynthetic machinery, combinatorial and engineered biosyntheses have yielded novel molecules with improved bioactivities. These studies will lay the foundation for the production of meroterpenoids with novel medicinal properties.

Identifiants

DOI: 10.1016/j.copbio.2020.11.016 PMID: 33383296
pubmed: 33383296
pii: S0958-1669(20)30183-X
doi: 10.1016/j.copbio.2020.11.016
pii:
doi:

Substances chimiques

Biological Products 0
Resorcinols 0
orsellinic acid 11XLA0494B

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

52-59

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

Auteurs

Hui Tao (H)

Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

Ikuro Abe (I)

Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; Collaborative Research Institute for Innovative Microbiology, The University of Tokyo, Yayoi 1-1-1, Bunkyo-ku, Tokyo 113-8657, Japan. Electronic address: abei@mol.f.u-tokyo.ac.jp.

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Classifications MeSH

questionsmedicales.fr › Mélanges complexes › Produits biologiques › Enzymology and biosynthesis of the orsellinic...
questionsmedicales.fr › Métabolisme › Voies et réseaux métaboliques › Voies de biosynthèse › Enzymology and biosynthesis of the orsellinic...
questionsmedicales.fr › Eucaryotes › Champignons › Enzymology and biosynthesis of the orsellinic...
questionsmedicales.fr › Disciplines des sciences naturelles › Disciplines des sciences biologiques › Biologie › Génétique › Génomique › Enzymology and biosynthesis of the orsellinic...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Résorcinol › Enzymology and biosynthesis of the orsellinic...