The Inositol Pyrophosphate Biosynthetic Pathway of
Journal
ACS chemical biology
ISSN: 1554-8937
Titre abrégé: ACS Chem Biol
Pays: United States
ID NLM: 101282906
Informations de publication
Date de publication:
19 02 2021
19 02 2021
Historique:
pubmed:
8
1
2021
medline:
29
6
2021
entrez:
7
1
2021
Statut:
ppublish
Résumé
Inositol phosphates (IPs) are phosphorylated derivatives of myo-inositol involved in the regulation of several cellular processes through their interaction with specific proteins. Their synthesis relies on the activity of specific kinases that use ATP as phosphate donor. Here, we combined reverse genetics and liquid chromatography coupled to mass spectrometry (LC-MS) to dissect the inositol phosphate biosynthetic pathway and its metabolic intermediates in the main life cycle stages (epimastigotes, cell-derived trypomastigotes, and amastigotes) of
Identifiants
pubmed: 33411501
doi: 10.1021/acschembio.0c00759
pmc: PMC10466500
mid: NIHMS1919352
doi:
Substances chimiques
Inositol Phosphates
0
Phosphotransferases (Alcohol Group Acceptor)
EC 2.7.1.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
283-292Subventions
Organisme : Medical Research Council
ID : MR/P027989/1
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : R01 AI108222
Pays : United States
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