γ-Hydroxybutyric Acid: Pharmacokinetics, Pharmacodynamics, and Toxicology.
Alcoholism
/ complications
Animals
Disease Models, Animal
Drug Evaluation, Preclinical
Drug Overdose
/ etiology
Humans
Hydroxybutyrates
/ administration & dosage
Metabolic Clearance Rate
Narcolepsy
/ drug therapy
Sodium Oxybate
/ administration & dosage
Substance Abuse, Oral
/ etiology
Substance Withdrawal Syndrome
/ drug therapy
GABAB receptors addiction
monocarboxylate transporters
narcolepsy
overdose treatment strategies
pharmacology
toxicity
Journal
The AAPS journal
ISSN: 1550-7416
Titre abrégé: AAPS J
Pays: United States
ID NLM: 101223209
Informations de publication
Date de publication:
08 01 2021
08 01 2021
Historique:
received:
13
10
2020
accepted:
23
11
2020
entrez:
8
1
2021
pubmed:
9
1
2021
medline:
5
10
2021
Statut:
epublish
Résumé
Gamma-hydroxybutyrate (GHB) is a short-chain fatty acid present endogenously in the brain and used therapeutically for the treatment of narcolepsy, as sodium oxybate, and for alcohol abuse/withdrawal. GHB is better known however as a drug of abuse and is commonly referred to as the "date-rape drug"; current use in popular culture includes recreational "chemsex," due to its properties of euphoria, loss of inhibition, amnesia, and drowsiness. Due to the steep concentration-effect curve for GHB, overdoses occur commonly and symptoms include sedation, respiratory depression, coma, and death. GHB binds to both GHB and GABA
Identifiants
pubmed: 33417072
doi: 10.1208/s12248-020-00543-z
pii: 10.1208/s12248-020-00543-z
pmc: PMC8098080
mid: NIHMS1693767
doi:
Substances chimiques
Hydroxybutyrates
0
4-hydroxybutyric acid
30IW36W5B2
Sodium Oxybate
7G33012534
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
22Subventions
Organisme : NIDA NIH HHS
ID : R01 DA023223
Pays : United States
Organisme : NIDA NIH HHS
ID : SC1 DA052120
Pays : United States
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