Acute effects of alcohol on resting-state functional connectivity in healthy young men.
Alcohol
Functional connectivity
fMRI
Journal
Addictive behaviors
ISSN: 1873-6327
Titre abrégé: Addict Behav
Pays: England
ID NLM: 7603486
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
03
09
2020
revised:
10
11
2020
accepted:
09
12
2020
pubmed:
10
1
2021
medline:
15
5
2021
entrez:
9
1
2021
Statut:
ppublish
Résumé
Alcohol abuse and dependence remain significant public health issues, and yet the brain circuits that are involved in the rewarding effects of alcohol are poorly understood. One promising way to study the effects of alcohol on neural activity is to examine its effects on functional connectivity between brain areas involved in reward and other functions. Here, we compared the effects of two doses of alcohol (0.4 and 0.8 g/kg) to placebo on resting-state functional connectivity in brain circuits related to reward in 19 healthy young men without histories of alcohol problems. The higher, but not the lower, dose of alcohol, significantly increased connectivity from reward-related regions to sensory and motor cortex, and between seeds associated with cognitive control. Contrary to expectation, alcohol did not significantly change connectivity for the ventral striatum at either dose. These findings reveal unrecognized effects of alcohol on connectivity from reward-related regions to visual and sensory cortical areas.
Identifiants
pubmed: 33421747
pii: S0306-4603(20)30915-1
doi: 10.1016/j.addbeh.2020.106786
pmc: PMC8693384
mid: NIHMS1761887
pii:
doi:
Substances chimiques
Ethanol
3K9958V90M
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
106786Subventions
Organisme : NIDA NIH HHS
ID : R01 DA002812
Pays : United States
Organisme : NIH HHS
ID : S10 OD018448
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
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