Acquired Hemophilia A in IgG4-Related Disease: Case Report, Immunopathogenic Study, and Review of the Literature.
Aged
Autoantibodies
/ immunology
Blood Coagulation
Blood Coagulation Tests
Disease Susceptibility
/ immunology
Factor VIII
/ immunology
Female
Hemophilia A
/ blood
Humans
Immunoglobulin G
/ immunology
Immunoglobulin G4-Related Disease
/ complications
Immunohistochemistry
Lymph Nodes
/ immunology
Male
T-Lymphocytes, Regulatory
/ immunology
IgG4 antibodies
IgG4-related disease
acquired hemophilia A
anti-factor VIII autoantibodies
plasma cell
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
04
05
2020
accepted:
16
11
2020
entrez:
11
1
2021
pubmed:
12
1
2021
medline:
20
5
2021
Statut:
epublish
Résumé
We report the observation of a 75-year-old patient referred for cervical lymphadenopathies. A pre-lymphadenectomy blood work revealed an asymptomatic elevation of aPTT with low factor VIII (FVIII) levels and high anti-FVIII antibodies titers, consistent with acquired hemophilia A (AHA). Histological work-up of a cervical lymphadenopathy revealed benign follicular hyperplasia with IgG4
Identifiants
pubmed: 33424828
doi: 10.3389/fimmu.2020.558811
pmc: PMC7793697
doi:
Substances chimiques
Autoantibodies
0
Immunoglobulin G
0
F8 protein, human
839MOZ74GK
Factor VIII
9001-27-8
Types de publication
Case Reports
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
558811Informations de copyright
Copyright © 2020 Sanges, Jeanpierre, Lopez, Russick, Delignat, Carpentier, Dubois, Dubucquoi, Guerrier, Hachulla, Hatron, Paris, Susen, Launay, Lacroix-Desmazes and Terriou.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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