Alterations of serum levels of plasminogen, TNF-α, and IDO in granulomatosis with polyangiitis patients.
Adult
Biomarkers
/ blood
Case-Control Studies
Cross-Sectional Studies
Female
Granulomatosis with Polyangiitis
/ blood
Humans
Indoleamine-Pyrrole 2,3,-Dioxygenase
/ blood
Lysosomal-Associated Membrane Protein 2
/ blood
Male
Middle Aged
Plasminogen
/ analysis
Predictive Value of Tests
Prognosis
Tumor Necrosis Factor-alpha
/ blood
Granulomatosis with polyangiitis
LAMP-2
granulomatosis serum levels of plasminogen
serum levels of indoleamine 2,3-dioxygenase
serum levels of tumor necrosis factor-alpha
Journal
Vascular
ISSN: 1708-539X
Titre abrégé: Vascular
Pays: England
ID NLM: 101196722
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
pubmed:
12
1
2021
medline:
25
11
2021
entrez:
11
1
2021
Statut:
ppublish
Résumé
Granulomatosis with polyangiitis (GPA) is a representative of vasculitides associated with anti-neutrophil cytoplasmic autoantibodies. "Classical" antibodies directed against proteinase 3 are involved in the pathogenesis and are part of the GPA diagnosis at the same time. Along with them, however, antibodies against Lysosomal-Associated Membrane Protein-2 (LAMP-2) and antibodies directed against plasminogen have been described in GPA. The results showed that in GPA, serum plasminogen levels were negatively associated with renal involvement (receiver operating characteristic (ROC) area under the curve (AUC) of 0.78) (95% CI 0.53-0.91), In this study, we demonstrate the alteration of soluble factors, which play an important role in the pathogenesis of GPA and their relationship with the clinical manifestations of the disease. Our main results confirm the associations of increased secretory TNF-α and some clinical manifestations, and we describe for the first time decreased serum plasminogen levels and their association with renal involvement.
Sections du résumé
BACKGROUND
BACKGROUND
Granulomatosis with polyangiitis (GPA) is a representative of vasculitides associated with anti-neutrophil cytoplasmic autoantibodies. "Classical" antibodies directed against proteinase 3 are involved in the pathogenesis and are part of the GPA diagnosis at the same time. Along with them, however, antibodies against Lysosomal-Associated Membrane Protein-2 (LAMP-2) and antibodies directed against plasminogen have been described in GPA.
RESULTS
RESULTS
The results showed that in GPA, serum plasminogen levels were negatively associated with renal involvement (receiver operating characteristic (ROC) area under the curve (AUC) of 0.78) (95% CI 0.53-0.91),
CONCLUSIONS
CONCLUSIONS
In this study, we demonstrate the alteration of soluble factors, which play an important role in the pathogenesis of GPA and their relationship with the clinical manifestations of the disease. Our main results confirm the associations of increased secretory TNF-α and some clinical manifestations, and we describe for the first time decreased serum plasminogen levels and their association with renal involvement.
Identifiants
pubmed: 33427113
doi: 10.1177/1708538120986305
doi:
Substances chimiques
Biomarkers
0
Indoleamine-Pyrrole 2,3,-Dioxygenase
0
LAMP2 protein, human
0
Lysosomal-Associated Membrane Protein 2
0
TNF protein, human
0
Tumor Necrosis Factor-alpha
0
Plasminogen
9001-91-6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM