The virulence of Salmonella Enteritidis in Galleria mellonella is improved by N-dodecanoyl-homoserine lactone.
Galleria mellonella
N-Dodecanoyl-homoserine lactone
Quorum sensing
Salmonella
Virulence
Journal
Microbial pathogenesis
ISSN: 1096-1208
Titre abrégé: Microb Pathog
Pays: England
ID NLM: 8606191
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
07
08
2020
revised:
01
01
2021
accepted:
03
01
2021
pubmed:
15
1
2021
medline:
22
6
2021
entrez:
14
1
2021
Statut:
ppublish
Résumé
Salmonella is a food and waterborne pathogen responsible for outbreaks worldwide, and it can survive during passage through the stomach and inside host phagocytic cells. Virulence genes are required for infection and survival in macrophages, and some are under the regulation of the quorum sensing (QS) system. This study investigated the influence of the autoinducer 1 (AI-1), N-dodecanoyl-homoserine lactone (C12-HSL), on the virulence of Salmonella PT4 using Galleria mellonella as an infection model. Salmonella PT4 was grown in the presence and absence of C12-HSL under anaerobic conditions for 7 h, and the expression of rpoS, arcA, arcB, and invA genes was evaluated. After the inoculation of G. mellonella with the median lethal dose (LD
Identifiants
pubmed: 33444697
pii: S0882-4010(21)00002-4
doi: 10.1016/j.micpath.2021.104730
pii:
doi:
Substances chimiques
homoserine lactone
1192-20-7
Homoserine
6KA95X0IVO
4-Butyrolactone
OL659KIY4X
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
104730Informations de copyright
Copyright © 2021. Published by Elsevier Ltd.