PharmVar GeneFocus: CYP2B6.

Alleles Cytochrome P-450 CYP2B6 / genetics Genetic Variation Haplotypes Humans Knowledge Bases Pharmacogenetics

Journal

Clinical pharmacology and therapeutics
ISSN: 1532-6535
Titre abrégé: Clin Pharmacol Ther
Pays: United States
ID NLM: 0372741

Informations de publication

Date de publication:
07 2021
Historique:
received: 21 10 2020
accepted: 21 12 2020
pubmed: 16 1 2021
medline: 28 7 2021
entrez: 15 1 2021
Statut: ppublish

Résumé

The Pharmacogene Variation Consortium (PharmVar) catalogs star (*) allele nomenclature for the polymorphic human CYP2B6 gene. Genetic variation within the CYP2B6 gene locus impacts the metabolism or bioactivation of clinically important drugs. Of particular importance are efficacy and safety concerns regarding: efavirenz, which is used for the treatment of HIV type-1 infection; methadone, a mainstay in the treatment of opioid use disorder and as an analgesic; ketamine, used as an antidepressant and analgesic; and bupropion, which is prescribed to treat depression and for smoking cessation. This GeneFocus provides a comprehensive overview and summary of CYP2B6 and describes how haplotype information catalogued by PharmVar is utilized by the Pharmacogenomics Knowledgebase (PharmGKB) and the Clinical Pharmacogenetics Implementation Consortium (CPIC).

Identifiants

DOI: 10.1002/cpt.2166 PMID: 33448339 PMC: PMC8693800
pubmed: 33448339
doi: 10.1002/cpt.2166
pmc: PMC8693800
mid: NIHMS1764617
doi:

Substances chimiques

CYP2B6 protein, human EC 1.14.14.1
Cytochrome P-450 CYP2B6 EC 1.14.14.1

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

82-97

Subventions

Organisme : NHGRI NIH HHS
ID : U24 HG010615
Pays : United States
Organisme : NIGMS NIH HHS
ID : R24 GM123930
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM078501
Pays : United States
Organisme : CIHR
ID : PJY-159710
Pays : Canada
Organisme : NIGMS NIH HHS
ID : R01 GM121707
Pays : United States

Informations de copyright

© 2021 The Authors. Clinical Pharmacology & Therapeutics © 2021 American Society for Clinical Pharmacology and Therapeutics.

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Auteurs

Zeruesenay Desta (Z)

Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Ahmed El-Boraie (A)

Centre for Addiction and Mental Health and Departments of Pharmacology & Toxicology, and Psychiatry, University of Toronto, Toronto, Canada.

Li Gong (L)

Department of Biomedical Data Science, Stanford University, Stanford, California, USA.

Andrew A Somogyi (AA)

Discipline of Pharmacology, Adelaide Medical School, University of Adelaide, Adelaide, Australia.

Volker M Lauschke (VM)

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

Collet Dandara (C)

Division of Human Genetics, Department of Pathology & Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

Kathrin Klein (K)

Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.
University of Tuebingen, Tuebingen, Germany.

Neil A Miller (NA)

Genomic Medicine Center, Children's Mercy, Kansas City, Missouri, USA.
School of Medicine, University of Missouri-Kansas City, Kansas City, Missouri, USA.

Teri E Klein (TE)

Department of Biomedical Data Science, Stanford University, Stanford, California, USA.

Rachel F Tyndale (RF)

Centre for Addiction and Mental Health and Departments of Pharmacology & Toxicology, and Psychiatry, University of Toronto, Toronto, Canada.

Michelle Whirl-Carrillo (M)

Department of Biomedical Data Science, Stanford University, Stanford, California, USA.

Andrea Gaedigk (A)

Division of Clinical Pharmacology, Toxicology & Therapeutic Innovation, Children's Mercy, Kansas City, Missouri, USA.
School of Medicine, University of Missouri-Kansas City, Kansas City, Missouri, USA.

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Classifications MeSH

questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Allèles › PharmVar GeneFocus: CYP2B6.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Hémoprotéines › Cytochromes › Cytochrome P-450 enzyme system › Famille-2 de cytochromes P450 › Cytochrome P-450 CYP2B6 › PharmVar GeneFocus: CYP2B6.
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › PharmVar GeneFocus: CYP2B6.
questionsmedicales.fr › Phénomènes génétiques › Génotype › Haplotypes › PharmVar GeneFocus: CYP2B6.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › PharmVar GeneFocus: CYP2B6.
questionsmedicales.fr › Sciences de l'information › Informatique › Informatique médicale › Applications de l'informatique médicale › Systèmes d'information › Bases de connaissances › PharmVar GeneFocus: CYP2B6.
questionsmedicales.fr › Professions de santé › Pharmacologie › Pharmacogénétique › PharmVar GeneFocus: CYP2B6.