Formation of Novel Octuplex DNA Molecules from Guanine Quadruplexes.
DNA nanoelectronics
guanine octuplex (G8-DNA)
guanine quadruplex (G4-DNA)
Journal
Advanced materials (Deerfield Beach, Fla.)
ISSN: 1521-4095
Titre abrégé: Adv Mater
Pays: Germany
ID NLM: 9885358
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
12
10
2020
revised:
14
12
2020
pubmed:
22
1
2021
medline:
7
10
2021
entrez:
21
1
2021
Statut:
ppublish
Résumé
Guanine quadruplex (G4)-DNA structures have sparked the interest of many scientists due to their important biological roles and their potential use in molecular nanoelectronics and nanotechnology. The high guanine content in G4-DNA endows it with mechanical stability, robustness, and improved charge transport properties-attractive attributes for a molecular nanowire. The self-driven formation of a novel G4-DNA-based nanostructure, coined guanine octuplex (G8)-DNA, is reported herein. Atomic force microscopy and scanning tunneling microscopy characterization of this molecule reveal its organized coiled-coil structure, which is found to be stable under different temperatures and surrounding conditions. G8-DNA exhibits enhanced stiffness, mechanical and thermodynamic stability when compared to its parent G4-DNA. These, along with its high guanine content, make G8-DNA a compelling new molecule, and a highly prospective candidate for molecular nanoelectronics.
Identifiants
pubmed: 33475220
doi: 10.1002/adma.202006932
doi:
Substances chimiques
DNA
9007-49-2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2006932Subventions
Organisme : Israel Science Foundation
ID : 1589/14
Organisme : Israel Science Foundation
ID : 2556/17
Organisme : Ministry of Science & Technology, Israel
ID : 3-16840
Informations de copyright
© 2021 Wiley-VCH GmbH.
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