The Tumor Profiler Study: integrated, multi-omic, functional tumor profiling for clinical decision support.

Clinical Decision-Making / methods Computational Biology / methods Decision Support Systems, Clinical Humans Neoplasms / genetics Precision Medicine / methods Prospective Studies

Journal

Cancer cell
ISSN: 1878-3686
Titre abrégé: Cancer Cell
Pays: United States
ID NLM: 101130617

Informations de publication

Date de publication:
08 03 2021
Historique:
pubmed: 23 1 2021
medline: 29 9 2021
entrez: 22 1 2021
Statut: ppublish

Résumé

The application and integration of molecular profiling technologies create novel opportunities for personalized medicine. Here, we introduce the Tumor Profiler Study, an observational trial combining a prospective diagnostic approach to assess the relevance of in-depth tumor profiling to support clinical decision-making with an exploratory approach to improve the biological understanding of the disease.

Identifiants

DOI: 10.1016/j.ccell.2021.01.004 PMID: 33482122
pubmed: 33482122
pii: S1535-6108(21)00048-9
doi: 10.1016/j.ccell.2021.01.004
pii:
doi:

Types de publication

Journal Article Observational Study Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

288-293

Investigateurs

Melike Ak (M)
Faisal S Al-Quaddoomi (FS)
Jonas Albinus (J)
Ilaria Alborelli (I)
Sonali Andani (S)
Per-Olof Attinger (PO)
Daniel Baumhoer (D)
Beatrice Beck-Schimmer (B)
Lara Bernasconi (L)
Anne Bertolini (A)
Natalia Chicherova (N)
Maya D'Costa (M)
Esther Danenberg (E)
Natalie Davidson (N)
Monica-Andreea Drăgan (MA)
Martin Erkens (M)
Katja Eschbach (K)
André Fedier (A)
Pedro Ferreira (P)
Bruno Frey (B)
Linda Grob (L)
Detlef Günther (D)
Martina Haberecker (M)
Pirmin Haeuptle (P)
Sylvia Herter (S)
Rene Holtackers (R)
Tamara Huesser (T)
Tim M Jaeger (TM)
Katharina Jahn (K)
Alva R James (AR)
Philip M Jermann (PM)
André Kahles (A)
Abdullah Kahraman (A)
Werner Kuebler (W)
Christian P Kunze (CP)
Christian Kurzeder (C)
Sebastian Lugert (S)
Gerd Maass (G)
Philipp Markolin (P)
Julian M Metzler (JM)
Simone Muenst (S)
Riccardo Murri (R)
Charlotte K Y Ng (CKY)
Stefan Nicolet (S)
Marta Nowak (M)
Patrick G A Pedrioli (PGA)
Salvatore Piscuoglio (S)
Mathilde Ritter (M)
Christian Rommel (C)
María L Rosano-González (ML)
Natascha Santacroce (N)
Ramona Schlenker (R)
Petra C Schwalie (PC)
Severin Schwan (S)
Tobias Schär (T)
Gabriela Senti (G)
Vipin T Sreedharan (VT)
Stefan Stark (S)
Tinu M Thomas (TM)
Vinko Tosevski (V)
Marina Tusup (M)
Audrey Van Drogen (A)
Marcus Vetter (M)
Tatjana Vlajnic (T)
Sandra Weber (S)
Walter P Weber (WP)
Michael Weller (M)
Fabian Wendt (F)
Norbert Wey (N)
Mattheus H E Wildschut (MHE)
Shuqing Yu (S)
Johanna Ziegler (J)
Marc Zimmermann (M)
Martin Zoche (M)
Gregor Zuend (G)

Informations de copyright

Copyright © 2021. Published by Elsevier Inc.

Déclaration de conflit d'intérêts

Declaration of Interests B.S. is scientific co-founder and shareholder of Allcyte GmbH. L.P. and G.G. are listed as inventor on patents related to the 4i technology (WO 2019/207004; WO 2020/008071). G.R., K.-V.L., and S.G.S. are listed on a patent application related to single-cell analyses (European Patent Application No. 20170724.7). H.M. is on advisory boards for Bayer, Astra Zeneca, Janssen, Roche, and Merck. R.D. reports intermittent, project-focused consulting and/or advisory relationships with Novartis, Merck Sharp & Dohme (MSD), Bristol Myers Squibb (BMS), Roche, Amgen, Takeda, Pierre Fabre, Sun Pharma, Sanofi, Catalym, Second Genome, Regeneron, and Alligator outside the submitted work. G.R. is cofounder and on the Scientific Advisory Board of Computomics GmbH. M.P.L. is a co-founder and shareholder of Oncobit AG and receives research funding from Novartis, Roche, and Molecular Partners. The Tumor Profiler study is jointly funded by a public-private partnership involving F. Hoffmann-La Roche Ltd., ETH Zurich, University of Zurich, University Hospital Zurich, and University Hospital Basel.

Auteurs

Anja Irmisch (A)

University Hospital Zurich, Department of Dermatology, University of Zurich, Gloriastrasse 31, 8091 Zurich, Switzerland.

Ximena Bonilla (X)

ETH Zurich, Department of Computer Science, Institute of Machine Learning, Universitätstrasse 6, 8092 Zurich, Switzerland; SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland; University Hospital Zurich, Biomedical Informatics, Schmelzbergstrasse 26, 8006 Zurich, Switzerland.

Stéphane Chevrier (S)

University of Zurich, Department of Quantitative Biomedicine, Winterthurerstrasse 190, 8057 Zurich, Switzerland.

Kjong-Van Lehmann (KV)

ETH Zurich, Department of Computer Science, Institute of Machine Learning, Universitätstrasse 6, 8092 Zurich, Switzerland; SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland; University Hospital Zurich, Biomedical Informatics, Schmelzbergstrasse 26, 8006 Zurich, Switzerland.

Franziska Singer (F)

SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland; ETH Zurich, NEXUS Personalized Health Technologies, John-von-Neumann-Weg 9, 8093 Zurich, Switzerland.

Nora C Toussaint (NC)

SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland; ETH Zurich, NEXUS Personalized Health Technologies, John-von-Neumann-Weg 9, 8093 Zurich, Switzerland.

Cinzia Esposito (C)

University of Zurich, Department of Molecular Life Sciences, Winterthurerstrasse 190, 8057 Zurich, Switzerland.

Julien Mena (J)

ETH Zurich, Department of Biology, Institute of Molecular Systems Biology, Otto-Stern-Weg 3, 8093 Zurich, Switzerland.

Emanuela S Milani (ES)

ETH Zurich, Department of Health Sciences and Technology, Otto-Stern-Weg 3, 8093 Zurich, Switzerland.

Ruben Casanova (R)

University of Zurich, Department of Quantitative Biomedicine, Winterthurerstrasse 190, 8057 Zurich, Switzerland.

Daniel J Stekhoven (DJ)

SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland; ETH Zurich, NEXUS Personalized Health Technologies, John-von-Neumann-Weg 9, 8093 Zurich, Switzerland.

Rebekka Wegmann (R)

ETH Zurich, Department of Biology, Institute of Molecular Systems Biology, Otto-Stern-Weg 3, 8093 Zurich, Switzerland.

Francis Jacob (F)

University Hospital Basel and University of Basel, Department of Biomedicine, Hebelstrasse 20, 4031 Basel, Switzerland.

Bettina Sobottka (B)

University Hospital Zurich, Department of Pathology and Molecular Pathology, Schmelzbergstrasse 12, 8091 Zurich, Switzerland.

Sandra Goetze (S)

ETH Zurich, Department of Health Sciences and Technology, Otto-Stern-Weg 3, 8093 Zurich, Switzerland.

Jack Kuipers (J)

SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland; ETH Zurich, Department of Biosystems Science and Engineering, Mattenstrasse 26, 4058 Basel, Switzerland.

Jacobo Sarabia Del Castillo (J)

University of Zurich, Department of Molecular Life Sciences, Winterthurerstrasse 190, 8057 Zurich, Switzerland.

Michael Prummer (M)

SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland; ETH Zurich, NEXUS Personalized Health Technologies, John-von-Neumann-Weg 9, 8093 Zurich, Switzerland.

Mustafa A Tuncel (MA)

SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland; ETH Zurich, Department of Biosystems Science and Engineering, Mattenstrasse 26, 4058 Basel, Switzerland.

Ulrike Menzel (U)

ETH Zurich, Department of Biosystems Science and Engineering, Mattenstrasse 26, 4058 Basel, Switzerland.

Andrea Jacobs (A)

University of Zurich, Department of Quantitative Biomedicine, Winterthurerstrasse 190, 8057 Zurich, Switzerland.

Stefanie Engler (S)

University of Zurich, Department of Quantitative Biomedicine, Winterthurerstrasse 190, 8057 Zurich, Switzerland.

Sujana Sivapatham (S)

University of Zurich, Department of Quantitative Biomedicine, Winterthurerstrasse 190, 8057 Zurich, Switzerland.

Anja L Frei (AL)

University Hospital Zurich, Department of Pathology and Molecular Pathology, Schmelzbergstrasse 12, 8091 Zurich, Switzerland.

Gabriele Gut (G)

University of Zurich, Department of Molecular Life Sciences, Winterthurerstrasse 190, 8057 Zurich, Switzerland.

Joanna Ficek (J)

ETH Zurich, Department of Computer Science, Institute of Machine Learning, Universitätstrasse 6, 8092 Zurich, Switzerland; SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland; University Hospital Zurich, Biomedical Informatics, Schmelzbergstrasse 26, 8006 Zurich, Switzerland.

Nicola Miglino (N)

University Hospital Zurich, Department of Medical Oncology and Hematology, Rämistrasse 100, 8091 Zurich, Switzerland.

Rudolf Aebersold (R)

ETH Zurich, Department of Biology, Institute of Molecular Systems Biology, Otto-Stern-Weg 3, 8093 Zurich, Switzerland.

Marina Bacac (M)

Roche Pharmaceutical Research and Early Development, Roche Innovation Center Zurich, Wagistrasse 10, 8952 Schlieren, Switzerland.

Niko Beerenwinkel (N)

SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland; ETH Zurich, Department of Biosystems Science and Engineering, Mattenstrasse 26, 4058 Basel, Switzerland.

Christian Beisel (C)

ETH Zurich, Department of Biosystems Science and Engineering, Mattenstrasse 26, 4058 Basel, Switzerland.

Bernd Bodenmiller (B)

University of Zurich, Department of Quantitative Biomedicine, Winterthurerstrasse 190, 8057 Zurich, Switzerland; ETH Zurich, Institute of Molecular Health Sciences, Otto-Stern-Weg 7, 8093 Zurich, Switzerland.

Reinhard Dummer (R)

University Hospital Zurich, Department of Dermatology, University of Zurich, Gloriastrasse 31, 8091 Zurich, Switzerland.

Viola Heinzelmann-Schwarz (V)

University Hospital Basel and University of Basel, Department of Biomedicine, Hebelstrasse 20, 4031 Basel, Switzerland; University Hospital Basel, Gynecological Cancer Center, Spitalstrasse 21, 4031 Basel, Switzerland.

Viktor H Koelzer (VH)

University Hospital Zurich, Department of Pathology and Molecular Pathology, Schmelzbergstrasse 12, 8091 Zurich, Switzerland.

Markus G Manz (MG)

University Hospital Zurich, Department of Medical Oncology and Hematology, Rämistrasse 100, 8091 Zurich, Switzerland.

Holger Moch (H)

University Hospital Zurich, Department of Pathology and Molecular Pathology, Schmelzbergstrasse 12, 8091 Zurich, Switzerland.

Lucas Pelkmans (L)

University of Zurich, Department of Molecular Life Sciences, Winterthurerstrasse 190, 8057 Zurich, Switzerland.

Berend Snijder (B)

SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland; ETH Zurich, Department of Biology, Institute of Molecular Systems Biology, Otto-Stern-Weg 3, 8093 Zurich, Switzerland.

Alexandre P A Theocharides (APA)

University Hospital Zurich, Department of Medical Oncology and Hematology, Rämistrasse 100, 8091 Zurich, Switzerland.

Markus Tolnay (M)

University Hospital Basel, Institute of Medical Genetics and Pathology, Schönbeinstrasse 40, 4031 Basel, Switzerland.

Andreas Wicki (A)

University Hospital Zurich, Department of Medical Oncology and Hematology, Rämistrasse 100, 8091 Zurich, Switzerland; University of Zurich, Faculty of Medicine, Zurich, Switzerland.

Bernd Wollscheid (B)

ETH Zurich, Department of Health Sciences and Technology, Otto-Stern-Weg 3, 8093 Zurich, Switzerland.

Gunnar Rätsch (G)

ETH Zurich, Department of Computer Science, Institute of Machine Learning, Universitätstrasse 6, 8092 Zurich, Switzerland; SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland; University Hospital Zurich, Biomedical Informatics, Schmelzbergstrasse 26, 8006 Zurich, Switzerland; ETH Zurich, Department of Biology, Wolfgang-Pauli-Strasse 27, 8093 Zurich, Switzerland. Electronic address: gunnar.raetsch@inf.ethz.ch.

Mitchell P Levesque (MP)

University Hospital Zurich, Department of Dermatology, University of Zurich, Gloriastrasse 31, 8091 Zurich, Switzerland. Electronic address: mitchell.levesque@usz.ch.

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Classifications MeSH

questionsmedicales.fr › Diagnostic › Prise de décision clinique › The Tumor Profiler Study: integrated,...
questionsmedicales.fr › Sciences de l'information › Informatique › Biologie informatique › The Tumor Profiler Study: integrated,...
questionsmedicales.fr › Sciences de l'information › Informatique › Informatique médicale › Applications de l'informatique médicale › Systèmes d'information › Systèmes d'aide à la décision clinique › The Tumor Profiler Study: integrated,...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The Tumor Profiler Study: integrated,...
questionsmedicales.fr › Tumeurs › The Tumor Profiler Study: integrated,...
questionsmedicales.fr › Professions de santé › Médecine › Médecine clinique › Médecine de précision › The Tumor Profiler Study: integrated,...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › The Tumor Profiler Study: integrated,...