TRPV4 channel activation induces the transition of venous and arterial endothelial cells toward a pro-inflammatory phenotype.
Antigens, CD
/ metabolism
Apoptosis
Cadherins
/ metabolism
Calcium Signaling
Cells, Cultured
Electric Impedance
Endothelial Cells
/ drug effects
Human Umbilical Vein Endothelial Cells
/ drug effects
Humans
Inflammation Mediators
/ metabolism
Intercellular Adhesion Molecule-1
/ genetics
Leucine
/ analogs & derivatives
NF-kappa B
/ metabolism
Permeability
Phenotype
Pulmonary Artery
/ drug effects
Sulfonamides
/ pharmacology
TRPV Cation Channels
/ agonists
ICAM-1
TRPV4 channel
VE-Cadherin
apoptosis
cytoskeleton
endothelial barrier
endothelial cells
Journal
Physiological reports
ISSN: 2051-817X
Titre abrégé: Physiol Rep
Pays: United States
ID NLM: 101607800
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
13
05
2020
revised:
20
09
2020
accepted:
22
09
2020
entrez:
29
1
2021
pubmed:
30
1
2021
medline:
15
12
2021
Statut:
ppublish
Résumé
The Transient Receptor Potential Vanilloid 4 (TRPV4) of endothelial cells contributes to many important functions including the regulation of Ca
Identifiants
pubmed: 33512067
doi: 10.14814/phy2.14613
pmc: PMC7845413
doi:
Substances chimiques
Antigens, CD
0
Cadherins
0
ICAM1 protein, human
0
Inflammation Mediators
0
N-(1-((4-(2-(((2,4-dichlorophenyl)sulfonyl)amino)-3-hydroxypropanoyl)-1-piperazinyl)carbonyl)-3-methylbutyl)-1-benzothiophene-2-carboxamide
0
NF-kappa B
0
Sulfonamides
0
TRPV Cation Channels
0
TRPV4 protein, human
0
cadherin 5
0
Intercellular Adhesion Molecule-1
126547-89-5
Leucine
GMW67QNF9C
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e14613Informations de copyright
© 2021 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.
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