Hippocampal D1-but not D2-like dopamine receptors modulate the phosphorylation of ERK in food deprivation-induced reinstatement of morphine in extinguished rats.
Analgesics, Opioid
Animals
Benzazepines
/ pharmacology
Dentate Gyrus
/ drug effects
Disease Models, Animal
Dopamine Antagonists
/ pharmacology
Dopamine D2 Receptor Antagonists
/ pharmacology
Extinction, Psychological
Extracellular Signal-Regulated MAP Kinases
/ drug effects
Food Deprivation
MAP Kinase Signaling System
/ drug effects
Morphine
Morphine Dependence
/ metabolism
Phosphorylation
Rats
Receptors, Dopamine D1
/ metabolism
Receptors, Dopamine D2
/ metabolism
Recurrence
Sulpiride
/ pharmacology
Journal
Neuroreport
ISSN: 1473-558X
Titre abrégé: Neuroreport
Pays: England
ID NLM: 9100935
Informations de publication
Date de publication:
03 03 2021
03 03 2021
Historique:
pubmed:
4
2
2021
medline:
21
12
2021
entrez:
3
2
2021
Statut:
ppublish
Résumé
Reinstatement to drug abuse is the most challenging issue in the treatment of addiction. Thus, knowledge of the involved neurobiological mechanisms of reinstatement is a fundamental necessity. There is substantial and crucial evidence that dopamine is implicated in motivational processes such as relapse. Our behavioral results reported that the administration of dopamine receptor antagonists inhibited reinstatement of morphine in food-deprived rats. Previous studies have indicated that the ERK pathway plays a critical role in the cellular responses to stress and reward. Therefore, the purpose of the current study was to evaluate the effect of intra-dentate gyrus administration of dopamine receptor antagonists on the phosphorylation of hippocampal ERK in the reinstatement phase of morphine reward in food-deprived rats. All groups of animals passed conditioned place preference and were bilaterally given different doses of D1- or D2-like dopamine compounds (0.25, 1 and 4 μg/0.5 μl) into the dentate gyrus. Immediately after the reinstatement phase, each animal was euthanized, and the hippocampi were immediately dissected. Then, the p-ERK/ERK ratio was evaluated using Western blot analysis. The principal findings in this study demonstrated that intra-dentate gyrus administration of the highest dose of the D1-like receptor antagonist could enhance the hippocampal p-ERK/ERK ratio in food-deprived rats while the D2-Like receptor antagonist failed to change this ratio.
Identifiants
pubmed: 33534372
doi: 10.1097/WNR.0000000000001597
pii: 00001756-202103010-00003
doi:
Substances chimiques
Analgesics, Opioid
0
Benzazepines
0
DRD2 protein, rat
0
Dopamine Antagonists
0
Dopamine D2 Receptor Antagonists
0
Drd1 protein, rat
0
Receptors, Dopamine D1
0
Receptors, Dopamine D2
0
SCH 23390
0
Morphine
76I7G6D29C
Sulpiride
7MNE9M8287
Extracellular Signal-Regulated MAP Kinases
EC 2.7.11.24
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
332-338Informations de copyright
Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.
Références
Shiffman S, Wills TA. Coping and substance use. San Diego: Academic Press; 1985.
Sinha R, Jastreboff AM. Stress as a common risk factor for obesity and addiction. Biol Psychiatry. 2013; 73:827–835.
Sahafzadeh M, Karimi-Haghighi S, Mousavi Z, Haghparast A. Role of the orexin receptors within the nucleus accumbens in the drug priming-induced reinstatement of morphine seeking in the food deprived rats. Brain Res Bull. 2018; 137:217–224.
Kim EJ, Pellman B, Kim JJ. Stress effects on the hippocampus: a critical review. Learn Mem. 2015; 22:411–416.
Karimi-Haghighi S, Haghparast A. Cannabidiol inhibits priming-induced reinstatement of methamphetamine in REM sleep deprived rats. Prog Neuropsychopharmacol Biol Psychiatry. 2018; 82:307–313.
Farzinpour Z, Taslimi Z, Azizbeigi R, Karimi-Haghighi S, Haghparast A. Involvement of orexinergic receptors in the nucleus accumbens, in the effect of forced swim stress on the reinstatement of morphine seeking behaviors. Behav Brain Res. 2019; 356:279–287.
Pahlevani P, Fatahi Z, Moradi M, Haghparast A. Morphine-induced conditioned place preference and the alterations of p-ERK, p-CREB and c-fos levels in hypothalamus and hippocampus: the effects of physical stress. Cell Mol Biol (Noisy-Le-Grand). 2014; 60:48–55.
Chen W, Nong Z, Li Y, Huang J, Chen C, Huang L. Role of dopamine signaling in drug addiction. Curr Top Med Chem. 2017; 17:2440–2455.
Cooper S, Robison AJ, Mazei-Robison MS. Reward circuitry in addiction. Neurotherapeutics. 2017; 14:687–697.
Swanson LW. The projections of the ventral tegmental area and adjacent regions: a combined fluorescent retrograde tracer and immunofluorescence study in the rat. Brain Res Bull. 1982; 9:321–353.
Katebi N, Farahimanesh S, Fatahi Z, Zarrabian S, Haghparast A. Involvement of D1- and D2-like dopamine receptors in the dentate gyrus in the acquisition, expression, and extinction of the morphine-induced conditioned place preference in rats. Behav Brain Res. 2018; 353:185–193.
Khakpour-Taleghani B, Reisi Z, Haghparast A. The blockade of D1/D2-like dopamine receptors within the dentate gyrus of hippocampus decreased the reinstatement of morphine-extinguished conditioned place preference in rats. Basic Clin Neurosci. 2015; 6:73–82.
Beaulieu JM, Gainetdinov RR. The physiology, signaling, and pharmacology of dopamine receptors. Pharmacol Rev. 2011; 63:182–217.
Kyosseva SV. Mitogen-activated protein kinase signaling. Int Rev Neurobiol. 2004; 59:201–220.
Berhow MT, Hiroi N, Nestler EJ. Regulation of ERK (extracellular signal regulated kinase), part of the neurotrophin signal transduction cascade, in the rat mesolimbic dopamine system by chronic exposure to morphine or cocaine. J Neurosci. 1996; 16:4707–4715.
Sun WL, Quizon PM, Zhu J. Molecular mechanism: ERK signaling, drug addiction, and behavioral effects. Prog Mol Biol Transl Sci. 2016; 137:1–40.
Cahill E, Salery M, Vanhoutte P, Caboche J. Convergence of dopamine and glutamate signaling onto striatal ERK activation in response to drugs of abuse. Front Pharmacol. 2014; 4:172.
Zhai H, Li Y, Wang X, Lu L. Drug-induced alterations in the extracellular signal-regulated kinase (ERK) signalling pathway: implications for reinforcement and reinstatement. Cell Mol Neurobiol. 2008; 28:157–172.
Xue B, Mao LM, Jin DZ, Wang JQ. Regulation of synaptic MAPK/ERK phosphorylation in the rat striatum and medial prefrontal cortex by dopamine and muscarinic acetylcholine receptors. J Neurosci Res. 2015; 93:1592–1599.
Mozafari R, Jamali S, Pourhamzeh M, Koruji M, Ahadi R, Haghparast A. The blockade of D1- and D2-like dopamine receptors within the dentate gyrus attenuates food deprivation stress-induced reinstatement of morphine-extinguished conditioned place preference in rats. Pharmacol Biochem Behav. 2020; 196:172967.
Haghparast A, Fatahi Z, Alamdary SZ, Reisi Z, Khodagholi F. Changes in the levels of p-ERK, p-CREB, and c-fos in rat mesocorticolimbic dopaminergic system after morphine-induced conditioned place preference: the role of acute and subchronic stress. Cell Mol Neurobiol. 2014; 34:277–288.
Paxinos G, Watson C. The rat brain in stereotaxic coordinates. San Diego: Elsevier Academic Press; 2007.
Haghparast A, Taslimi Z, Ramin M, Azizi P, Khodagholi F, Hassanpour-Ezatti M. Changes in phosphorylation of CREB, ERK, and c-fos induction in rat ventral tegmental area, hippocampus and prefrontal cortex after conditioned place preference induced by chemical stimulation of lateral hypothalamus. Behav Brain Res. 2011; 220:112–118.
Hooshmandi E, Motamedi F, Moosavi M, Katinger H, Zakeri Z, Zaringhalam J, et al. CEPO-Fc (an EPO derivative) protects hippocampus against Aβ-induced memory deterioration: a behavioral and molecular study in a rat model of Aβ toxicity. Neuroscience. 2018; 388:405–417.
Karimi-Haghighi S, Dargahi L, Haghparast A. Cannabidiol modulates the expression of neuroinflammatory factors in stress- and drug-induced reinstatement of methamphetamine in extinguished rats. Addict Biol. 2020; 25:e12740.
Duman CH, Schlesinger L, Kodama M, Russell DS, Duman RS. A role for MAP kinase signaling in behavioral models of depression and antidepressant treatment. Biol Psychiatry. 2007; 61:661–670.
Iñiguez SD, Vialou V, Warren BL, Cao JL, Alcantara LF, Davis LC, et al. Extracellular signal-regulated kinase-2 within the ventral tegmental area regulates responses to stress. J Neurosci. 2010; 30:7652–7663.
Lv XF, Sun LL, Cui CL, Han JS. NAc shell Arc/Arg3.1 protein mediates reconsolidation of morphine CPP by increased GluR1 cell surface expression: activation of ERK-coupled CREB is required. Int J Neuropsychopharmacol. 2015; 18:pyv030.
Yap JJ, Chartoff EH, Holly EN, Potter DN, Carlezon WA Jr, Miczek KA. Social defeat stress-induced sensitization and escalated cocaine self-administration: the role of ERK signaling in the rat ventral tegmental area. Psychopharmacology (Berl). 2015; 232:1555–1569.
Tanaka T, Kai N, Kobayashi K, Takano Y, Hironaka N. Up-regulation of dopamine D1 receptor in the hippocampus after establishment of conditioned place preference by cocaine. Neuropharmacology. 2011; 61:842–848.
Neve KA, Seamans JK, Trantham-Davidson H. Dopamine receptor signaling. J Recept Signal Transduct Res. 2004; 24:165–205.
Yan Z, Feng J, Fienberg AA, Greengard P. D(2) dopamine receptors induce mitogen-activated protein kinase and cAMP response element-binding protein phosphorylation in neurons. Proc Natl Acad Sci U S A. 1999; 96:11607–11612.
Sinha R. The role of stress in addiction relapse. Curr Psychiatry Rep. 2007; 9:388–395.
Deak M, Clifton AD, Lucocq LM, Alessi DR. Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. EMBO J. 1998; 17:4426–4441.
Sánchez I, Hughes RT, Mayer BJ, Yee K, Woodgett JR, Avruch J, et al. Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun. Nature. 1994; 372:794–798.
Shen CP, Tsimberg Y, Salvadore C, Meller E. Activation of Erk and JNK MAPK pathways by acute swim stress in rat brain regions. BMC Neurosci. 2004; 5:36.
Qi X, Lin W, Li J, Li H, Wang W, Wang D, Sun M. Fluoxetine increases the activity of the ERK-CREB signal system and alleviates the depressive-like behavior in rats exposed to chronic forced swim stress. Neurobiol Dis. 2008; 31:278–285.