FATC Domain Deletion Compromises ATM Protein Stability, Blocks Lymphocyte Development, and Promotes Lymphomagenesis.
Animals
Ataxia Telangiectasia Mutated Proteins
/ genetics
Carcinogenesis
/ genetics
Cell Differentiation
/ genetics
Codon, Nonsense
Disease Models, Animal
Gene Knock-In Techniques
Humans
Lymphocytes
/ immunology
Lymphoma
/ genetics
Male
Mice
Mice, Knockout
Protein Domains
/ genetics
Protein Stability
V(D)J Recombination
/ genetics
Journal
Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R
Informations de publication
Date de publication:
15 03 2021
15 03 2021
Historique:
received:
20
08
2020
accepted:
04
01
2021
pubmed:
5
2
2021
medline:
6
8
2021
entrez:
4
2
2021
Statut:
ppublish
Résumé
Ataxia-telangiectasia mutated (ATM) kinase is a master regulator of the DNA damage response, and loss of ATM leads to primary immunodeficiency and greatly increased risk for lymphoid malignancies. The FATC domain is conserved in phosphatidylinositol-3-kinase-related protein kinases (PIKKs). Truncation mutation in the FATC domain (R3047X) selectively compromised reactive oxygen species-induced ATM activation in cell-free assays. In this article, we show that in mouse models, knock-in ATM-R3057X mutation (
Identifiants
pubmed: 33536256
pii: jimmunol.2000967
doi: 10.4049/jimmunol.2000967
pmc: PMC9305077
mid: NIHMS1661647
doi:
Substances chimiques
Codon, Nonsense
0
Ataxia Telangiectasia Mutated Proteins
EC 2.7.11.1
Atm protein, mouse
EC 2.7.11.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1228-1239Subventions
Organisme : NCI NIH HHS
ID : R01 CA226852
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA013696
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM102362
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA158073
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA184187
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA215067
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA174653
Pays : United States
Informations de copyright
Copyright © 2021 by The American Association of Immunologists, Inc.
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