The Added Value of Baseline Circulating Tumor DNA Profiling in Patients with Molecularly Hyperselected, Left-sided Metastatic Colorectal Cancer.

Antineoplastic Combined Chemotherapy Protocols / adverse effects Biomarkers, Tumor Circulating Tumor DNA Colorectal Neoplasms / diagnosis High-Throughput Nucleotide Sequencing Humans Kaplan-Meier Estimate Liquid Biopsy / methods Male Mutation Panitumumab / administration & dosage Prognosis Proto-Oncogene Proteins B-raf / genetics Transcriptome Tumor Burden ras Proteins / genetics

Journal

Clinical cancer research : an official journal of the American Association for Cancer Research

ISSN: 1557-3265

Titre abrégé: Clin Cancer Res

Pays: United States

ID NLM: 9502500

Informations de publication

Date de publication:
01 05 2021

Historique:

received: 03 12 2020

revised: 08 01 2021

accepted: 29 01 2021

pubmed: 7 2 2021

medline: 17 3 2022

entrez: 6 2 2021

Statut: ppublish

Résumé

The routine use of liquid biopsy is not recommended for the choice of initial treatment for patients with metastatic colorectal cancer (mCRC). We included patients with left-sided, Ten and 15 of 120 patients had a mutation of Baseline ctDNA profiling may add value to tumor tissue testing to refine the molecular hyperselection of patients with mCRC for upfront anti-EGFR-based strategies.

Identifiants

DOI: 10.1158/1078-0432.CCR-20-4699 PMID: 33547199

pubmed: 33547199

pii: 1078-0432.CCR-20-4699

doi: 10.1158/1078-0432.CCR-20-4699

doi:

Substances chimiques

Biomarkers, Tumor 0

Circulating Tumor DNA 0

Panitumumab 6A901E312A

Proto-Oncogene Proteins B-raf EC 2.7.11.1

ras Proteins EC 3.6.5.2

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Pagination

2505-2514

Informations de copyright

Références

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