Describing variability in pig genes involved in coronavirus infections for a One Health perspective in conservation of animal genetic resources.
Angiotensin-Converting Enzyme 2
/ genetics
Animals
Breeding
CD13 Antigens
/ genetics
Coronavirus Infections
/ genetics
Dipeptidyl Peptidase 4
/ genetics
Gene Frequency
Genetic Variation
Genetics, Population
High-Throughput Nucleotide Sequencing
Humans
INDEL Mutation
One Health
Polymorphism, Single Nucleotide
Receptors, Virus
/ genetics
Serine Endopeptidases
/ genetics
Sus scrofa
/ genetics
Swine
Whole Genome Sequencing
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
09 02 2021
09 02 2021
Historique:
received:
14
08
2020
accepted:
25
01
2021
entrez:
10
2
2021
pubmed:
11
2
2021
medline:
13
2
2021
Statut:
epublish
Résumé
Coronaviruses silently circulate in human and animal populations, causing mild to severe diseases. Therefore, livestock are important components of a "One Health" perspective aimed to control these viral infections. However, at present there is no example that considers pig genetic resources in this context. In this study, we investigated the variability of four genes (ACE2, ANPEP and DPP4 encoding for host receptors of the viral spike proteins and TMPRSS2 encoding for a host proteinase) in 23 European (19 autochthonous and three commercial breeds and one wild boar population) and two Asian Sus scrofa populations. A total of 2229 variants were identified in the four candidate genes: 26% of them were not previously described; 29 variants affected the protein sequence and might potentially interact with the infection mechanisms. The results coming from this work are a first step towards a "One Health" perspective that should consider conservation programs of pig genetic resources with twofold objectives: (i) genetic resources could be reservoirs of host gene variability useful to design selection programs to increase resistance to coronaviruses; (ii) the described variability in genes involved in coronavirus infections across many different pig populations might be part of a risk assessment including pig genetic resources.
Identifiants
pubmed: 33564056
doi: 10.1038/s41598-021-82956-0
pii: 10.1038/s41598-021-82956-0
pmc: PMC7873263
doi:
Substances chimiques
Receptors, Virus
0
CD13 Antigens
EC 3.4.11.2
Dipeptidyl Peptidase 4
EC 3.4.14.5
Angiotensin-Converting Enzyme 2
EC 3.4.17.23
Serine Endopeptidases
EC 3.4.21.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3359Subventions
Organisme : Horizon 2020
ID : No. 634476 - TREASURE project
Organisme : Università di Bologna
ID : RFO 2016-2019 programmes
Organisme : Ministero dell'Istruzione, dell'Università e della Ricerca
ID : PigPhenomics project
Organisme : EGI
ID : AnGen1H project
Organisme : Por Fesr Emilia-Romagna 2014-2020
ID : LIVESTOCK-STOP-COVI project
Organisme : European Open Science Cloud
ID : VirAnimalOne project
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