Down syndrome with neonatal alloimmune thrombocytopenia due to anti-HLA A31 and B61 antibodies.
Down syndrome
Human leukocyte antigen
Human platelet antigen
Neonatal alloimmune thrombocytopenia
Journal
International journal of hematology
ISSN: 1865-3774
Titre abrégé: Int J Hematol
Pays: Japan
ID NLM: 9111627
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
received:
15
09
2020
accepted:
28
01
2021
revised:
26
01
2021
pubmed:
12
2
2021
medline:
1
6
2021
entrez:
11
2
2021
Statut:
ppublish
Résumé
Neonatal alloimmune thrombocytopenia (NAIT) arises from fetomaternal platelet incompatibility that results in transplacental passage of maternal antibodies mostly against fetal human platelet antigens (HPA), whereas NAIT due to anti-human leukocyte antigen (HLA) antibodies is extremely rare. Here, we report a case of Down syndrome (DS) with NAIT that was attributed to HLA antibodies. A boy with DS was delivered at 36 weeks' gestation. His platelet count declined to 13.0 × 10
Identifiants
pubmed: 33569741
doi: 10.1007/s12185-021-03092-z
pii: 10.1007/s12185-021-03092-z
doi:
Substances chimiques
Autoantibodies
0
HLA-A Antigens
0
HLA-A31 antigen
0
HLA-B Antigens
0
HLA-B61 antigen
0
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
945-949Références
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