Resting-state hippocampal networks related to language processing reveal unique patterns in temporal lobe epilepsy.

Brain Mapping Epilepsy, Temporal Lobe / diagnostic imaging Functional Laterality Hippocampus / diagnostic imaging Humans Magnetic Resonance Imaging Temporal Lobe / diagnostic imaging
Functional connectivity Hippocampus Language MRI Temporal lobe epilepsy

Journal

Epilepsy & behavior : E&B
ISSN: 1525-5069
Titre abrégé: Epilepsy Behav
Pays: United States
ID NLM: 100892858

Informations de publication

Date de publication:
04 2021
Historique:
received: 23 12 2020
revised: 22 01 2021
accepted: 26 01 2021
pubmed: 21 2 2021
medline: 21 4 2021
entrez: 20 2 2021
Statut: ppublish

Résumé

Patients with temporal lobe epilepsy (TLE) commonly experience a broad range of language impairments. These deficits are thought to arise from repeated seizure activity that damages language regions. However, connectivity between the seizure onset region in the hippocampus and regions related to language processing has rarely been studied, and could also have a strong impact on language function. The purpose of this study was to use resting-state functional connectivity (FC) measures to assess hippocampal network patterns and their relation to language abilities in patients with right TLE (RLTE), left TLE (LTLE), and healthy controls. Presurgical resting-state 3T functional MRI data were acquired from 40 patients with mesial TLE (27 RTLE, 13 LTLE) and 54 controls. The regions of interest were the anterior and posterior bilateral hippocampi and eleven regions grouped by frontal or temporo-parietal locations, including large areas of language-related cortex. FC values were computed with the right/left anterior and posterior hippocampi as the seeds and frontal and temporo-parietal regions as targets. Resting-state lateralization indices were also calculated (LI-Rest), and all FC measures were correlated to neuropsychological language scores and measures related to manifestation of epilepsy including age of onset, duration of disease, monthly seizure frequency, and hippocampal volume. We found significant group differences between the anterior hippocampi and temporo-parietal regions closest to the seizure focus, in which RTLE and LTLE showed stronger connectivity to their contralateral hippocampus, while controls showed similar connectivity to both hippocampi. In addition, LI-Rest demonstrated significantly more right lateralization in LTLE compared to RTLE for temporo-parietal regions only. In LTLE, we found significant associations between stronger hippocampal network resting-state FC and later age of onset and decreased left anterior hippocampal volume. The results of our study indicate that the presence of TLE impacts hippocampal-temporo-parietal networks relevant to language processing.

Identifiants

DOI: 10.1016/j.yebeh.2021.107834 PMID: 33610102 PMC: PMC8035309
pubmed: 33610102
pii: S1525-5050(21)00068-8
doi: 10.1016/j.yebeh.2021.107834
pmc: PMC8035309
mid: NIHMS1671523
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

107834

Subventions

Organisme : NINDS NIH HHS
ID : R01 NS075270
Pays : United States
Organisme : NIBIB NIH HHS
ID : T32 EB001628
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS112252
Pays : United States
Organisme : NINDS NIH HHS
ID : F31 NS106735
Pays : United States
Organisme : NIH HHS
ID : S10 OD021771
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007347
Pays : United States
Organisme : NICHD NIH HHS
ID : P50 HD103537
Pays : United States
Organisme : NINDS NIH HHS
ID : R00 NS097618
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS108445
Pays : United States
Organisme : NIBIB NIH HHS
ID : T32 EB021937
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS110130
Pays : United States

Informations de copyright

Copyright © 2021 Elsevier Inc. All rights reserved.

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Auteurs

Allison Whitten (A)

Institute of Imaging Science, Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, USA.

Monica L Jacobs (ML)

Department of Neurological Surgery, Vanderbilt University Medical Center, USA.

Dario J Englot (DJ)

Institute of Imaging Science, Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, USA; Department of Neurological Surgery, Vanderbilt University Medical Center, USA; Department of Biomedical Engineering, Vanderbilt University, USA.

Baxter P Rogers (BP)

Institute of Imaging Science, Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, USA; Department of Biomedical Engineering, Vanderbilt University, USA.

Kaela K Levine (KK)

Institute of Imaging Science, Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, USA.

Hernán F J González (HFJ)

Institute of Imaging Science, Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, USA; Department of Biomedical Engineering, Vanderbilt University, USA.

Victoria L Morgan (VL)

Institute of Imaging Science, Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, USA; Department of Neurological Surgery, Vanderbilt University Medical Center, USA; Department of Biomedical Engineering, Vanderbilt University, USA. Electronic address: victoria.morgan@vanderbilt.edu.

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questionsmedicales.fr › Techniques d'investigation › Neuroimagerie › Neuroimagerie fonctionnelle › Cartographie cérébrale › Resting-state hippocampal networks related to...
questionsmedicales.fr › Maladies du système nerveux › Maladies du système nerveux central › Encéphalopathies › Épilepsie › Syndromes épileptiques › Épilepsie temporale › Resting-state hippocampal networks related to...
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