Cardiovascular phenotype of the
Animals
Calcium
/ metabolism
Calcium Channels, L-Type
/ metabolism
Cardiomyopathies
/ pathology
Cardiomyopathy, Dilated
/ complications
Cardiovascular System
Disease Models, Animal
Dystrophin
/ genetics
Endothelium, Vascular
/ pathology
Fibrosis
/ pathology
Heart Ventricles
/ physiopathology
Hemodynamics
Homeostasis
Humans
Inflammation
Kidney
/ metabolism
Lung
/ metabolism
Muscle, Skeletal
/ pathology
Muscular Dystrophy, Duchenne
/ genetics
Myocardium
/ pathology
Myocytes, Cardiac
/ metabolism
Oxidative Stress
Peptidyl-Dipeptidase A
Phenotype
Rats
Stress, Mechanical
Cardiomyocyte
Cardiovascular dysfunction
Muscular dystrophy
Rat
Remodeling
Journal
Disease models & mechanisms
ISSN: 1754-8411
Titre abrégé: Dis Model Mech
Pays: England
ID NLM: 101483332
Informations de publication
Date de publication:
22 02 2021
22 02 2021
Historique:
received:
08
10
2020
accepted:
23
12
2020
entrez:
23
2
2021
pubmed:
24
2
2021
medline:
19
1
2022
Statut:
epublish
Résumé
Besides skeletal muscle abnormalities, Duchenne muscular dystrophy (DMD) patients present with dilated cardiomyopathy development, which considerably contributes to morbidity and mortality. Because the mechanisms responsible for the cardiac complications in the context of DMD are largely unknown, evidence-based therapy approaches are still lacking. This has increased the need for basic research efforts into animal models for DMD. Here, we characterized in detail the cardiovascular abnormalities of
Identifiants
pubmed: 33619211
pii: 14/2/dmm047704
doi: 10.1242/dmm.047704
pmc: PMC7927653
pii:
doi:
Substances chimiques
CACNA1C protein, human
0
Calcium Channels, L-Type
0
DMD protein, human
0
Dmd protein, rat
0
Dystrophin
0
Peptidyl-Dipeptidase A
EC 3.4.15.1
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Austrian Science Fund FWF
ID : P 30234
Pays : Austria
Informations de copyright
© 2021. Published by The Company of Biologists Ltd.
Déclaration de conflit d'intérêts
Competing interestsThe authors declare no competing or financial interests.
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