Fragmentation study of tryptophan-derived metabolites induced by electrospray ionization mass spectrometry for highly sensitive analysis.

Chromatography, Liquid Ions Spectrometry, Mass, Electrospray Ionization Tandem Mass Spectrometry Tryptophan

Journal

The Analyst
ISSN: 1364-5528
Titre abrégé: Analyst
Pays: England
ID NLM: 0372652

Informations de publication

Date de publication:
07 Apr 2021
Historique:
pubmed: 24 2 2021
medline: 15 5 2021
entrez: 23 2 2021
Statut: ppublish

Résumé

Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is interfaced with electrospray ionization (ESI), which generally produces intact gas-phase ions of biomolecules. However, ESI induces the fragmentation of tryptophan-derived metabolites, which are known to act as neurotransmitters and psychoactive drugs. Tryptophan-derived metabolites undergo N-C

Identifiants

DOI: 10.1039/d0an02069a PMID: 33620043
pubmed: 33620043
doi: 10.1039/d0an02069a
doi:

Substances chimiques

Ions 0
Tryptophan 8DUH1N11BX

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

2292-2300

Auteurs

Daiki Asakawa (D)

National Institute of Advanced Industrial Science and Technology, 1-1-1 Umezono, Tsukuba, Ibaraki 305-8568, Japan. d.asakawa@aist.go.jp.

Hajime Mizuno (H)

Eiji Sugiyama (E)

Kenichiro Todoroki (K)

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Classifications MeSH

questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Chromatographie › Chromatographie en phase liquide › Fragmentation study of tryptophan-derived...
questionsmedicales.fr › Produits chimiques inorganiques › Électrolytes › Ions › Fragmentation study of tryptophan-derived...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Spectrométrie de masse › Spectrométrie de masse ESI › Fragmentation study of tryptophan-derived...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Spectrométrie de masse › Spectrométrie de masse en tandem › Fragmentation study of tryptophan-derived...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés essentiels › Tryptophane › Fragmentation study of tryptophan-derived...