Small molecule-induced trinucleotide repeat contractions during in vitro DNA synthesis.

DNA / genetics DNA Replication / drug effects Electrophoresis, Capillary Humans Ligands Naphthyridines / pharmacology Nucleic Acid Conformation / drug effects Quinolones / pharmacology Trinucleotide Repeats / drug effects

Journal

Chemical communications (Cambridge, England)
ISSN: 1364-548X
Titre abrégé: Chem Commun (Camb)
Pays: England
ID NLM: 9610838

Informations de publication

Date de publication:
04 Apr 2021
Historique:
pubmed: 2 3 2021
medline: 16 7 2021
entrez: 1 3 2021
Statut: ppublish

Résumé

We demonstrated that a synthetic ligand NA, which selectively binds to a 5'-CAG-3'/5'-CAG-3' triad, induced repeat contractions during DNA polymerase-mediated primer extension through the CAG repeat template. A thorough capillary electrophoresis and sequencing analysis revealed that the d(CAG)

Identifiants

DOI: 10.1039/d1cc00349f PMID: 33646236
pubmed: 33646236
doi: 10.1039/d1cc00349f
doi:

Substances chimiques

Ligands 0
Naphthyridines 0
Quinolones 0
naphthyridine-azaquinolone 0
DNA 9007-49-2

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

3235-3238

Auteurs

Chikara Dohno (C)

The Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan. cdohno@sanken.osaka-u.ac.jp nakatani@sanken.osaka-u.ac.jp.

Masaki Hagihara (M)

Nursakinah Binti Mohd Zaifuddin (N)

Mizuki Nihei (M)

Kaoru Saito (K)

Kazuhiko Nakatani (K)

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Classifications MeSH

questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › Small molecule-induced trinucleotide repeat...
questionsmedicales.fr › Phénomènes génétiques › Réplication de l'ADN › Small molecule-induced trinucleotide repeat...
questionsmedicales.fr › Techniques d'investigation › Techniques électrochimiques › Électrophorèse › Électrophorèse capillaire › Small molecule-induced trinucleotide repeat...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Small molecule-induced trinucleotide repeat...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › Small molecule-induced trinucleotide repeat...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Naphtyridines › Small molecule-induced trinucleotide repeat...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Conformation d'acide nucléique › Small molecule-induced trinucleotide repeat...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Quinoléines › Quinolinone › Small molecule-induced trinucleotide repeat...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Séquences répétées en tandem › Répétitions microsatellites › Répétitions de trinucléotides › Small molecule-induced trinucleotide repeat...