ASimulatoR: splice-aware RNA-Seq data simulation.
Journal
Bioinformatics (Oxford, England)
ISSN: 1367-4811
Titre abrégé: Bioinformatics
Pays: England
ID NLM: 9808944
Informations de publication
Date de publication:
29 09 2021
29 09 2021
Historique:
received:
29
09
2020
revised:
16
02
2021
accepted:
25
02
2021
pubmed:
2
3
2021
medline:
2
2
2023
entrez:
1
3
2021
Statut:
ppublish
Résumé
A plethora of tools exist for RNA-Seq data analysis with a focus on alternative splicing (AS). However, appropriate data for their comparative evaluation is missing. The R package ASimulatoR simulates gold standard RNA-Seq datasets with fine-grained control over the distribution of AS events, which allow for evaluating alternative splicing tools, e.g. to study the effect of sequencing depth on the performance of AS event detection. ASimulatoR is freely available at https://github.com/biomedbigdata/ASimulatoR as an R package under GPL-3 license.
Identifiants
pubmed: 33647976
pii: 6153968
doi: 10.1093/bioinformatics/btab142
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3008-3010Subventions
Organisme : European Union's Horizon 2020 research and innovation programme
ID : 777111
Organisme : German Federal Ministry of Education and Research
ID : 01ZX1908A
Organisme : Deutsche Forschungsgemeinschaft
ID : 395357507
Informations de copyright
© The Author(s) 2021. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.